3IMX
Crystal Structure of human glucokinase in complex with a synthetic activator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucokinase | polymer | 455 | 50908.8 | 1 | UniProt (Q53Y25) Pfam (PF00349) Pfam (PF03727) UniProt (by SIFTS) (P35557) | Homo sapiens (human) | Hexokinase 4, maturity onset diabetes of the young 2, isoform CRA_b |
| 2 | B (A) | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
| 3 | C (A) | (2R)-3-cyclopentyl-N-(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)-2-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}propanamide | non-polymer | 543.7 | 1 | Chemie (B84) | |||
| 4 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | E (A) | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
A: 16 - 465 (UniProt: Q53Y25)
| PDB | External Database | Details |
|---|---|---|
| Gly 11 | - | expression tag |
| Pro 12 | - | expression tag |
| Gly 13 | - | expression tag |
| Ser 14 | - | expression tag |
| Met 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 50908.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 746.8 | |
| All* | Total formula weight | 51655.6 |
