PDB: 334 件ウェブページステータス検索Chemie searchBIRD

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2TSC	STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Montfort, W.R, Stroud, R.M. 登録日 1991-07-03 公開日 1991-10-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry, 29, 1990
3TMS	PLASTIC ADAPTATION TOWARD MUTATIONS IN PROTEINS: STRUCTURAL COMPARISON OF THYMIDYLATE SYNTHASES 分子名称: PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Perry, K.M, Stroud, R.M. 登録日 1991-09-19 公開日 1991-10-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins, 8, 1990
4TMS	PLASTIC ADAPTATION TOWARD MUTATIONS IN PROTEINS: STRUCTURAL COMPARISON OF THYMIDYLATE SYNTHASES 分子名称: PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R. 登録日 1992-01-07 公開日 1992-01-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins, 8, 1990
2BBQ	STRUCTURAL BASIS FOR RECOGNITION OF POLYGLUTAMYL FOLATES BY THYMIDYLATE SYNTHASE 分子名称: 10-PARPARGYL-5,8-DIDEAZAFOLATE-4-GLUTAMIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Kamb, A, Finer-Moore, J, Stroud, R.M. 登録日 1992-09-16 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for recognition of polyglutamyl folates by thymidylate synthase. Biochemistry, 31, 1992
1TDB	STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE 分子名称: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Perry, K.M, Carreras, C.W, Chang, L.C, Santi, D.V, Stroud, R.M. 登録日 1993-02-15 公開日 1993-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry, 32, 1993
1TDC	STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Perry, K.M, Carreras, C.W, Chang, L.C, Santi, D.V, Stroud, R.M. 登録日 1993-02-15 公開日 1993-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry, 32, 1993
1TDA	STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE 分子名称: PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Perry, K.M, Carreras, C.W, Chang, L.C, Santi, D.V, Stroud, R.M. 登録日 1993-02-15 公開日 1993-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry, 32, 1993
1THY	REFINED STRUCTURES OF SUBSTRATE-BOUND AND PHOSPHATE-BOUND THYMIDYLATE SYNTHASE FROM LACTOBACILLUS CASEI 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R. 登録日 1993-04-02 公開日 1993-10-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
2TDD	STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE 分子名称: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-HYDROXYMETHYLENE-6-HYDROFOLIC ACID, THYMIDYLATE SYNTHASE 著者 Perry, K.M, Carreras, C.W, Chang, L.C, Santi, D.V, Stroud, R.M. 登録日 1993-04-05 公開日 1993-07-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry, 32, 1993
1TYS	WATER-MEDIATED SUBSTRATE(SLASH)PRODUCT DISCRIMINATION: THE PRODUCT COMPLEX OF THYMIDYLATE SYNTHASE AT 1.83 ANGSTROMS 分子名称: DIHYDROFOLIC ACID, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE SYNTHASE 著者 Fauman, E, Rutenber, E, Stroud, R. 登録日 1993-05-07 公開日 1994-06-22 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A. Biochemistry, 33, 1994
1TIS	CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM T4 PHAGE 分子名称: PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R. 登録日 1994-01-24 公開日 1994-04-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex. Biochemistry, 33, 1994
1TLC	THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89 分子名称: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, THYMIDYLATE SYNTHASE 著者 Weichsel, A, Montfort, W.R, Ciesla, J, Maley, F. 登録日 1995-03-07 公開日 1995-06-03 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89. Proc.Natl.Acad.Sci.USA, 92, 1995
1LCA	LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Birdsall, D.L, Finer-Moore, J, Stroud, R.M. 登録日 1995-06-22 公開日 1995-10-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
1LCE	LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CH2THF 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID, THYMIDYLATE SYNTHASE 著者 Birdsall, D.L, Finer-Moore, J, Stroud, R.M. 登録日 1995-06-22 公開日 1995-10-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
1LCB	LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DTMP AND H2FOLATE 分子名称: DIHYDROFOLIC ACID, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE SYNTHASE 著者 Birdsall, D.L, Finer-Moore, J, Stroud, R.M. 登録日 1995-06-22 公開日 1995-10-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
1TSD	THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, BETA-MERCAPTOETHANOL, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, ... 著者 Weichsel, A, Montfort, W.R. 登録日 1995-08-15 公開日 1996-01-29 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89. Nat.Struct.Biol., 2, 1995
1SYN	E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, THYMIDYLATE SYNTHASE 著者 Stout, T.J, Stroud, R.M. 登録日 1995-09-19 公開日 1996-01-29 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition. Structure, 4, 1996
1TSY	THYMIDYLATE SYNTHASE R179K MUTANT 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1995-12-05 公開日 1996-03-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
1TSV	THYMIDYLATE SYNTHASE R179A MUTANT 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1995-12-05 公開日 1996-03-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
1TSX	THYMIDYLATE SYNTHASE R179E MUTANT 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1995-12-05 公開日 1996-03-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
1TSZ	THYMIDYLATE SYNTHASE R179K MUTANT 分子名称: PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1995-12-05 公開日 1996-03-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
1TSW	THYMIDYLATE SYNTHASE R179A MUTANT 分子名称: PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1995-12-05 公開日 1996-03-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9, 1996
1NJE	THYMIDYLATE SYNTHASE WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP) 分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1996-01-23 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996
1NJB	THYMIDYLATE SYNTHASE 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1996-01-23 公開日 1996-10-14 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996
1NJA	THYMIDYLATE SYNTHASE, MUTATION, N229C WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP) 分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1996-01-23 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996

 

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