1TDC

STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE

Summary for 1TDC

Entry DOI	10.2210/pdb1tdc/pdb
Descriptor	THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (2 entities in total)
Functional Keywords	transferase (methyltransferase)
Biological source	Lactobacillus casei
Cellular location	Cytoplasm: P00469
Total number of polymer chains	1
Total formula weight	36839.51
Authors	Perry, K.M.,Carreras, C.W.,Chang, L.C.,Santi, D.V.,Stroud, R.M. (deposition date: 1993-02-15, release date: 1993-07-15, Last modification date: 2024-02-14)
Primary citation	Perry, K.M.,Carreras, C.W.,Chang, L.C.,Santi, D.V.,Stroud, R.M. Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry, 32:7116-7125, 1993 Cited by PubMed: 8343503 DOI: 10.1021/bi00079a007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation