1TSD
THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89
Summary for 1TSD
Entry DOI | 10.2210/pdb1tsd/pdb |
Descriptor | THYMIDYLATE SYNTHASE, BETA-MERCAPTOETHANOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | dump, 1843u89, transferase (methyltransferase) |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 62860.96 |
Authors | Weichsel, A.,Montfort, W.R. (deposition date: 1995-08-15, release date: 1996-01-29, Last modification date: 2018-04-18) |
Primary citation | Weichsel, A.,Montfort, W.R. Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89. Nat.Struct.Biol., 2:1095-1101, 1995 Cited by PubMed: 8846221DOI: 10.1038/nsb1295-1095 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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