2TSC

STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE

Summary for 2TSC

• Entry DOI: 10.2210/pdb2tsc/pdb
• Descriptor: THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
• Functional Keywords: transferase (methyltransferase)
• Biological source: Escherichia coli
• Cellular location: Cytoplasm: P0A884
• Total number of polymer chains: 2
• Total formula weight: 62486.41

Authors

Montfort, W.R.,Stroud, R.M. (deposition date: 1991-07-03, release date: 1991-10-15, Last modification date: 2011-07-13)

• Primary citation: Montfort, W.R.,Perry, K.M.,Fauman, E.B.,Finer-Moore, J.S.,Maley, G.F.,Hardy, L.,Maley, F.,Stroud, R.M.; Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.; Biochemistry, 29:6964-6977, 1990; PubMed: 2223754; DOI: 10.1021/bi00482a004

Experimental method

X-RAY DIFFRACTION (1.97 Å)