2TSC
STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | THYMIDYLATE SYNTHASE | polymer | 264 | 30457.6 | 2 | UniProt (P0A884) Pfam (PF00303) | Escherichia coli | |
| 2 | C, E (A, B) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) PubChem (688) PubChem (65063) PubChem (446899) PubChem (446900) PubChem (57164254) PubChem (71773959) PubChem (92144438) PubChem (92209480) PubChem (92209481) PubChem (92209482) PubChem (92449733) PubChem (133126534) | |||
| 3 | D, F (A, B) | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID | non-polymer | 477.5 | 2 | Chemie (CB3) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 264 (UniProt: P0A884)
| PDB | External Database | Details |
|---|---|---|
| Ala 235 | Lys 235 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60915.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1571.3 | |
| All* | Total formula weight | 62486.4 |
