1SYN

E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)

Summary for 1SYN
DescriptorTHYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, ... (4 entities in total)
Functional Keywordstransferase (methyltransferase)
Biological sourceEscherichia coli
Cellular locationCytoplasm: P0A884
Total number of polymer chains2
Total formula weight62704.69
Authors
Stout, T.J.,Stroud, R.M. (deposition date: 1995-09-19, release date: 1996-01-29, Last modification date: 2011-07-13)
Primary citationStout, T.J.,Stroud, R.M.
The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
Structure, 4:67-77, 1996
PubMed: 8805515
DOI: 110.1016/S0969-2126(96)00010-X
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation
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PDB entries from 2021-06-16