1SYN
E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)
Summary for 1SYN
| Descriptor | THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, ... (4 entities in total) |
| Functional Keywords | transferase (methyltransferase) |
| Biological source | Escherichia coli |
| Cellular location | Cytoplasm: P0A884 |
| Total number of polymer chains | 2 |
| Total formula weight | 62704.69 |
| Authors | Stout, T.J.,Stroud, R.M. (deposition date: 1995-09-19, release date: 1996-01-29, Last modification date: 2011-07-13) |
| Primary citation | Stout, T.J.,Stroud, R.M. The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition. Structure, 4:67-77, 1996 PubMed: 8805515 DOI: 110.1016/S0969-2126(96)00010-X PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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