1TSX

THYMIDYLATE SYNTHASE R179E MUTANT

Summary for 1TSX

Entry DOI	10.2210/pdb1tsx/pdb
Descriptor	THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (3 entities in total)
Functional Keywords	transferase, methyltransferase, nucleotide biosynthesis
Biological source	Lactobacillus casei
Cellular location	Cytoplasm: P00469
Total number of polymer chains	1
Total formula weight	36910.56
Authors	Finer-Moore, J.,Stroud, R.M. (deposition date: 1995-12-05, release date: 1996-03-08, Last modification date: 2024-02-14)
Primary citation	Finer-Moore, J.S.,Fauman, E.B.,Morse, R.J.,Santi, D.V.,Stroud, R.M. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng., 9:69-75, 1996 Cited by PubMed: 9053905 DOI: 10.1093/protein/9.1.69 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation