PDB: 729 件ウェブページステータス検索Chemie searchBIRD

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4S0G	Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide 分子名称: Peptide from Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 著者 Chen, K.-E, Meng, T.C, Wang, A.H.-J. 登録日 2014-12-31 公開日 2015-03-11 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.723 Å) 主引用文献 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4Y14	Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-Nalpha-(methylsulfonyl)-L-phenylalaninamide, CHLORIDE ION, ... 著者 Choy, M.S, Connors, C, Page, R, Peti, W. 登録日 2015-02-06 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.898 Å) 主引用文献 PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J.Clin.Invest., 125, 2015
6H8S	CRYSTAL STRUCTURE OF THE MOUSE PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND BI-0314 分子名称: 1-[3-piperidin-4-yl-5-(trifluoromethyl)phenyl]guanidine, Tyrosine-protein phosphatase non-receptor type 5 著者 Fiegen, D, Schnapp, G. 登録日 2018-08-03 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.771 Å) 主引用文献 Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. J. Med. Chem., 62, 2019
8JBY	Vascular endothelial protein tyrosine phosphatase in complex with Cpd-2 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-(hydroxymethyl)-5-(1-methylindol-3-yl)-1,2-oxazole-3-carboxylic acid, ... 著者 Orita, T, Furuzono, T, Doi, S, Adachi, T. 登録日 2023-05-10 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques. Biochemistry, 62, 2023
8JBN	Vascular endothelial protein tyrosine phosphatase in complex with Cpd-1 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-(1~{H}-indol-3-yl)-1,2-oxazole-3-carboxylic acid, ... 著者 Orita, T, Furuzono, T, Doi, S, Adachi, T. 登録日 2023-05-09 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques. Biochemistry, 62, 2023
6SUC	Human PTPRU D1 domain, oxidised form 分子名称: Receptor-type tyrosine-protein phosphatase U 著者 Hay, I.M, Fearnley, G.W, Sharpe, H.J, Deane, J.E. 登録日 2019-09-13 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 The receptor PTPRU is a redox sensitive pseudophosphatase. Nat Commun, 11, 2020
6SUB	Human PTPRU D1 domain, reduced form 分子名称: CHLORIDE ION, Receptor-type tyrosine-protein phosphatase U 著者 Hay, I.M, Fearnley, G.W, Sharpe, H.J, Deane, J.E. 登録日 2019-09-13 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 The receptor PTPRU is a redox sensitive pseudophosphatase. Nat Commun, 11, 2020
5OVR	X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors 分子名称: Tyrosine-protein phosphatase non-receptor type 5, [(~{S})-[4-[3-[(~{R})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid 著者 Kack, H, Wissler, L. 登録日 2017-08-29 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60, 2017
5OVX	X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors 分子名称: Tyrosine-protein phosphatase non-receptor type 5, [(~{S})-[4-[3-[(~{S})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid 著者 Kack, H, Wissler, L. 登録日 2017-08-30 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60, 2017
5OW1	X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors 分子名称: Tyrosine-protein phosphatase non-receptor type 5, [[3-(3-cyclohexyl-2-oxidanyl-phenyl)phenyl]-bis(fluoranyl)methyl]phosphonic acid 著者 Kack, H, Wissler, L. 登録日 2017-08-30 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60, 2017
7F5O	Crystal structure of PTPN2 catalytic domain 分子名称: IODIDE ION, Tyrosine-protein phosphatase non-receptor type 2 著者 Singh, J.P, Lin, M.-J, Hsu, S.-F, Lee, C.-C, Meng, T.-C. 登録日 2021-06-22 公開日 2021-12-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix alpha 7 in Phosphatase Activity. Biochemistry, 60, 2021
7F5N	Crystal structure of TCPTP catalytic domain 分子名称: Tyrosine-protein phosphatase non-receptor type 2 著者 Singh, J.P, Lin, M.-J, Hsu, S.-F, Lee, C.-C, Meng, T.-C. 登録日 2021-06-22 公開日 2021-12-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix alpha 7 in Phosphatase Activity. Biochemistry, 60, 2021
6UZT	Crystal Structure of RPTP alpha 分子名称: Receptor-type tyrosine-protein phosphatase alpha 著者 Santelli, E, Wen, Y, Yang, S, Svensson, M.N.D, Stanford, S.M, Bottini, N. 登録日 2019-11-15 公開日 2020-03-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 RPTP alpha phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. J.Biol.Chem., 295, 2020
8CT8	Crystal structure of Drosophila melanogaster PRL/CBS-pair domain complex 分子名称: IODIDE ION, PRL-1 phosphatase, Unextended protein 著者 Fakih, R, Goldstein, R.H, Kozlov, G, Gehring, K. 登録日 2022-05-13 公開日 2023-03-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Burst kinetics and CNNM binding are evolutionarily conserved properties of phosphatases of regenerating liver. J.Biol.Chem., 299, 2023
7TVJ	Crystal Structure of Monobody Mb(SHP2PTP_13)/SHP2 PTP Domain Complex 分子名称: CITRATE ANION, Mb(SHP2PTP_13), Tyrosine-protein phosphatase non-receptor type 11 著者 Sha, F, Koide, S. 登録日 2022-02-05 公開日 2023-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation. J.Mol.Biol., 435, 2023
7UAD	Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484 分子名称: 5-{(7R)-1-fluoro-3-hydroxy-7-[(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, Tyrosine-protein phosphatase non-receptor type 2 著者 Longenecker, K.L, Qiu, W, Sun, Q, Frost, J.M. 登録日 2022-03-12 公開日 2023-07-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.044 Å) 主引用文献 The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature, 622, 2023
6W30	Protein Tyrosine Phosphatase 1B Bound to Amorphadiene 分子名称: Amorphadiene, GLYCEROL, MAGNESIUM ION, ... 著者 Sarkar, A, Kim, E.Y, Hongdusit, A, Sankaran, B, Fox, J. 登録日 2020-03-08 公開日 2021-05-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Microbially Guided Discovery and Biosynthesis of Biologically Active Natural Products. Acs Synth Biol, 10, 2021
8DU7	Room-temperature serial synchrotron crystallography (SSX) structure of apo PTP1B 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 著者 Ebrahim, A, Sharma, S, Keedy, D.A. 登録日 2022-07-27 公開日 2022-08-17 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B. Acta Crystallogr.,Sect.F, 79, 2023
7XC0	Crystal structure of Human RPTPH 分子名称: PHOSPHATE ION, Receptor-type tyrosine-protein phosphatase H 著者 Kim, M, Ryu, S.E. 登録日 2022-03-22 公開日 2022-07-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Crystal structure of the catalytic domain of human RPTPH. Acta Crystallogr.,Sect.F, 78, 2022
3I36	Crystal Structure of Rat Protein Tyrosine Phosphatase eta Catalytic Domain 分子名称: CHLORIDE ION, Vascular protein tyrosine phosphatase 1 著者 Nascimento, A.S, Matozo, H.C, Santos, M.A, Polikarpov, I. 登録日 2009-06-30 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.841 Å) 主引用文献 To be Published To be Published
3I7Z	Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ... 著者 Brandao, T.A.S, Johnson, S.J, Hengge, A.C. 登録日 2009-07-09 公開日 2010-03-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
3I80	Protein Tyrosine Phosphatase 1B - Transition state analog for the second catalytic step 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... 著者 Brandao, T.A.S, Johnson, S.J, Hengge, A.C. 登録日 2009-07-09 公開日 2010-03-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010
3MOW	Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1 分子名称: (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10S,12S,15E,17E)-18-carboxy-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5-oxooctade ca-15,17-dien-1-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, Tyrosine-protein phosphatase non-receptor type 11 著者 Zhang, Z.-Y, Liu, S, Yu, Z, Yu, X. 登録日 2010-04-23 公開日 2011-05-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1 To be Published
3M4U	Crystal Structure of Trypanosoma brucei Protein Tyrosine Phosphatase TbPTP1 分子名称: PHOSPHATE ION, Tyrosine specific protein phosphatase, putative 著者 Chou, S, Alber, T, Grundner, C. 登録日 2010-03-12 公開日 2010-05-05 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.392 Å) 主引用文献 The Trypanosoma brucei life cycle switch TbPTP1 is structurally conserved and dephosphorylates the nucleolar protein NOPP44/46. J.Biol.Chem., 285, 2010
4BJO	Nitrate in the active site of PTP1b is a putative mimetic of the transition state 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... 著者 Kenny, P.W, Newman, J, Peat, T.S. 登録日 2013-04-19 公開日 2014-02-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Nitrate in the Active Site of Protein Tyrosine Phosphatase 1B is a Putative Mimetic of the Transition State. Acta Crystallogr.,Sect.D, 70, 2014

 

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