7UAD

Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484

Summary for 7UAD

• Entry DOI: 10.2210/pdb7uad/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 2, 5-{(7R)-1-fluoro-3-hydroxy-7-[(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione (3 entities in total)
• Functional Keywords: phosphatase, inhibitor, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38351.45

Authors

Longenecker, K.L.,Qiu, W.,Sun, Q.,Frost, J.M. (deposition date: 2022-03-12, release date: 2023-07-26, Last modification date: 2023-11-08)

• Primary citation: Baumgartner, C.K.,Ebrahimi-Nik, H.,Iracheta-Vellve, A.,Hamel, K.M.,Olander, K.E.,Davis, T.G.R.,McGuire, K.A.,Halvorsen, G.T.,Avila, O.I.,Patel, C.H.,Kim, S.Y.,Kammula, A.V.,Muscato, A.J.,Halliwill, K.,Geda, P.,Klinge, K.L.,Xiong, Z.,Duggan, R.,Mu, L.,Yeary, M.D.,Patti, J.C.,Balon, T.M.,Mathew, R.,Backus, C.,Kennedy, D.E.,Chen, A.,Longenecker, K.,Klahn, J.T.,Hrusch, C.L.,Krishnan, N.,Hutchins, C.W.,Dunning, J.P.,Bulic, M.,Tiwari, P.,Colvin, K.J.,Chuong, C.L.,Kohnle, I.C.,Rees, M.G.,Boghossian, A.,Ronan, M.,Roth, J.A.,Wu, M.J.,Suermondt, J.S.M.T.,Knudsen, N.H.,Cheruiyot, C.K.,Sen, D.R.,Griffin, G.K.,Golub, T.R.,El-Bardeesy, N.,Decker, J.H.,Yang, Y.,Guffroy, M.,Fossey, S.,Trusk, P.,Sun, I.M.,Liu, Y.,Qiu, W.,Sun, Q.,Paddock, M.N.,Farney, E.P.,Matulenko, M.A.,Beauregard, C.,Frost, J.M.,Yates, K.B.,Kym, P.R.,Manguso, R.T.; The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.; Nature, 622:850-862, 2023; PubMed: 37794185; DOI: 10.1038/s41586-023-06575-7

Experimental method

X-RAY DIFFRACTION (2.044 Å)