7UAD

Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein phosphatase non-receptor type 2	polymer	324	37966.0	1	UniProt (P17706) Pfam (PF00102) In PDB	Homo sapiens (human)	T-cell protein-tyrosine phosphatase,TCPTP
2	A	5-{(7R)-1-fluoro-3-hydroxy-7-[(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione	non-polymer		385.5	1	Chemie (M5R)
3		water	water		18.0	145	Chemie (HOH)

Sequence modifications

A: 1 - 314 (UniProt: P17706)

PDB	External Database	Details
Met -1	-	expression tag
Ala 0	-	expression tag
His 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37966.0
Non-Polymers*	Number of molecules	1
	Total formula weight	385.5
All*	Total formula weight	38351.5

*Water molecules are not included.