4Y14

Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633)

Summary for 4Y14

Entry DOI	10.2210/pdb4y14/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, CHLORIDE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total)
Functional Keywords	tyrosine inhibitor complex, hydrolase, protein binding, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains	2
Total formula weight	73159.69
Authors	Choy, M.S.,Connors, C.,Page, R.,Peti, W. (deposition date: 2015-02-06, release date: 2015-08-05, Last modification date: 2023-09-27)
Primary citation	Krishnan, N.,Krishnan, K.,Connors, C.R.,Choy, M.S.,Page, R.,Peti, W.,Van Aelst, L.,Shea, S.D.,Tonks, N.K. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J.Clin.Invest., 125:3163-3177, 2015 Cited by PubMed: 26214522 DOI: 10.1172/JCI80323 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.898 Å)

Structure validation