4Y14
Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 308 | 35796.7 | 2 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (Human) | Protein-tyrosine phosphatase 1B,PTP-1B |
| 2 | C, D, E, J, K (A, B) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 3 | F, G, L (A, B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 3 | Chemie (TRS) | |||
| 4 | H (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | I, M (A, B) | 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-Nalpha-(methylsulfonyl)-L-phenylalaninamide | non-polymer | 465.2 | 2 | Chemie (C0A) | |||
| 6 | N, O (A, B) | water | water | 18.0 | 539 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 301 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| His -3 | - | expression tag |
| Met -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Met 1 | - | expression tag |
| His 302 | - | expression tag |
| Asn 303 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71593.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1566.2 | |
| All* | Total formula weight | 73159.7 |
