Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
A | 0006470 | biological_process | protein dephosphorylation |
A | 0016311 | biological_process | dephosphorylation |
B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
B | 0006470 | biological_process | protein dephosphorylation |
B | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | binding site for residue CL A 401 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue CL A 402 |
Chain | Residue |
A | ARG24 |
A | ARG254 |
A | GLN262 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CL A 403 |
Chain | Residue |
A | ARG112 |
A | VAL113 |
A | HIS175 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue TRS A 404 |
Chain | Residue |
A | ASP22 |
A | HOH501 |
A | HOH528 |
B | GLU293 |
B | HIS296 |
B | ASP298 |
B | LEU299 |
A | ALA18 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue TRS A 405 |
Chain | Residue |
A | LYS128 |
A | GLU129 |
A | GLU130 |
A | HOH517 |
A | HOH519 |
B | HIS54 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue GOL A 406 |
Chain | Residue |
A | PRO89 |
A | MET133 |
A | PHE135 |
A | HOH514 |
A | HOH696 |
site_id | AC7 |
Number of Residues | 15 |
Details | binding site for residue C0A A 407 |
Chain | Residue |
A | TYR46 |
A | ASP48 |
A | ASP181 |
A | PHE182 |
A | CYS215 |
A | SER216 |
A | ALA217 |
A | GLY218 |
A | ILE219 |
A | GLY220 |
A | ARG221 |
A | GLN262 |
A | HOH559 |
A | HOH709 |
A | HOH770 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue CL B 401 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue CL B 402 |
Chain | Residue |
B | ARG112 |
B | VAL113 |
B | HIS175 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue TRS B 403 |
Chain | Residue |
A | HIS54 |
B | GLU129 |
B | GLU130 |
B | HOH607 |
site_id | AD2 |
Number of Residues | 14 |
Details | binding site for residue C0A B 404 |
Chain | Residue |
B | TYR46 |
B | ASP48 |
B | ASP181 |
B | PHE182 |
B | CYS215 |
B | SER216 |
B | ALA217 |
B | GLY218 |
B | ILE219 |
B | GLY220 |
B | ARG221 |
B | GLN262 |
B | HOH584 |
B | HOH623 |
Functional Information from PROSITE/UniProt
site_id | PS00383 |
Number of Residues | 11 |
Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRSG |
Chain | Residue | Details |
A | VAL213-GLY223 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Phosphocysteine intermediate |
Chain | Residue | Details |
A | CYS215 | |
B | CYS215 | |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP181 | |
B | ASP181 | |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | CYS215 | |
A | GLN262 | |
B | CYS215 | |
B | GLN262 | |
Chain | Residue | Details |
A | TYR20 | |
B | TYR20 | |
Chain | Residue | Details |
A | SER50 | |
B | SER50 | |
Chain | Residue | Details |
A | TYR66 | |
B | TYR66 | |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: S-nitrosocysteine; in reversibly inhibited form => ECO:0000269|PubMed:22169477 |
Chain | Residue | Details |
A | CYS215 | |
B | CYS215 | |
Chain | Residue | Details |
A | SER242 | |
A | SER243 | |
B | SER242 | |
B | SER243 | |
Chain | Residue | Details |
A | CYS215 | |
A | SER216 | |
B | CYS215 | |
B | SER216 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 469 |
Chain | Residue | Details |
A | ASP181 | proton shuttle (general acid/base) |
A | CYS215 | covalent catalysis |
A | ARG221 | activator, electrostatic stabiliser |
A | SER222 | activator, electrostatic stabiliser |
A | GLN262 | steric role |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 469 |
Chain | Residue | Details |
B | ASP181 | proton shuttle (general acid/base) |
B | CYS215 | covalent catalysis |
B | ARG221 | activator, electrostatic stabiliser |
B | SER222 | activator, electrostatic stabiliser |
B | GLN262 | steric role |