8JBN

Vascular endothelial protein tyrosine phosphatase in complex with Cpd-1

Summary for 8JBN

• Entry DOI: 10.2210/pdb8jbn/pdb
• Descriptor: Receptor-type tyrosine-protein phosphatase beta, 1,2-ETHANEDIOL, 5-(1~{H}-indol-3-yl)-1,2-oxazole-3-carboxylic acid, ... (5 entities in total)
• Functional Keywords: protein tyrosine phosphatase, fbdd, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 68765.65

Authors

Orita, T.,Furuzono, T.,Doi, S.,Adachi, T. (deposition date: 2023-05-09, release date: 2024-02-28)

• Primary citation: Asano, W.,Yamanaka, K.,Ohara, Y.,Uhara, T.,Doi, S.,Orita, T.,Iwanaga, T.,Adachi, T.,Fujioka, S.,Akaki, T.,Ikegashira, K.,Hantani, Y.; Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques.; Biochemistry, 62:2161-2169, 2023; PubMed: 37414577; DOI: 10.1021/acs.biochem.3c00079

Experimental method

X-RAY DIFFRACTION (1.99 Å)