5OVR

X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors

Summary for 5OVR

Entry DOI	10.2210/pdb5ovr/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 5, [(~{S})-[4-[3-[(~{R})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid (3 entities in total)
Functional Keywords	phosphatase alzheimer's disease inhibitor step, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane ; Multi-pass membrane protein : P54829
Total number of polymer chains	1
Total formula weight	35660.07
Authors	Kack, H.,Wissler, L. (deposition date: 2017-08-29, release date: 2017-11-22, Last modification date: 2024-01-17)
Primary citation	Witten, M.R.,Wissler, L.,Snow, M.,Geschwindner, S.,Read, J.A.,Brandon, N.J.,Nairn, A.C.,Lombroso, P.J.,Kack, H.,Ellman, J.A. X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60:9299-9319, 2017 Cited by PubMed: 29116812 DOI: 10.1021/acs.jmedchem.7b01292 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation