5OVR

X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue AXK A 601

Chain	Residue
A	ASN376
A	ARG478
A	GLN520
A	HOH720
A	HOH734
A	HOH774
A	GLU378
A	GLU379
A	SER434
A	TRP435
A	PRO436
A	ASP437
A	LYS439
A	ARG443

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Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG

Chain	Residue	Details
A	VAL470-GLY480

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044

Chain	Residue	Details
A	THR504

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ILE469

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	THR504

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MAPK => ECO:0000269|PubMed:21777200

Chain	Residue	Details
A	ALA263

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK => ECO:0000269|PubMed:21777200

Chain	Residue	Details
A	LEU276

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