3I80
Protein Tyrosine Phosphatase 1B - Transition state analog for the second catalytic step
Summary for 3I80
Entry DOI | 10.2210/pdb3i80/pdb |
Related | 1A5Y 1PTU 2CM2 2HNQ 3I7Z |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total) |
Functional Keywords | hydrolase, p-loop, wpd-loop, protein phosphatase, vanadate, acetylation, endoplasmic reticulum, membrane, oxidation, phosphoprotein, polymorphism |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 37879.00 |
Authors | Brandao, T.A.S.,Johnson, S.J.,Hengge, A.C. (deposition date: 2009-07-09, release date: 2010-03-16, Last modification date: 2023-09-06) |
Primary citation | Brandao, T.A.,Hengge, A.C.,Johnson, S.J. Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285:15874-15883, 2010 Cited by PubMed: 20236928DOI: 10.1074/jbc.M109.066951 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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