8YX9
| CD40 in complex with Dacetuzumab Fab | 分子名称: | Dacetuzumab, Heavy chain, light chain, ... | 著者 | Caaveiro, J.M.M, Fernandez-Perez, J, Tsumoto, K. | 登録日 | 2024-04-02 | 公開日 | 2024-05-08 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structures of human CD40 in complex with monoclonal antibodies dacetuzumab and bleselumab. Biochem.Biophys.Res.Commun., 714, 2024
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8YX1
| CD40 in complex with Bleselumab Fab | 分子名称: | Bleselumab, heavy chain, light chain, ... | 著者 | Caaveiro, J.M.M, Fernandez-Perez, J, Tsumoto, K. | 登録日 | 2024-04-01 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structures of human CD40 in complex with monoclonal antibodies dacetuzumab and bleselumab. Biochem.Biophys.Res.Commun., 714, 2024
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8P6Q
| Racemic structure of TNFR1 cysteine-rich domain | 分子名称: | D-TNFR-1 CRD2, SULFATE ION, Tumor necrosis factor-binding protein 1 | 著者 | Lander, A.J, Jin, Y, Luk, L.Y.P. | 登録日 | 2023-05-28 | 公開日 | 2024-01-24 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and d-Peptide Ligand Discovery. Acs Bio Med Chem Au, 4, 2024
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8OZ3
| Crystal structure of scFv ATOR 1017 bound to human 4-1BB | 分子名称: | Single chain Fv, Tumor necrosis factor receptor superfamily member 9 | 著者 | Hakansson, M, Von Schantz, L, Rose, N. | 登録日 | 2023-05-08 | 公開日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1. Cancer Immunol.Immunother., 72, 2023
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8HLB
| Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2 | 分子名称: | TR109 heavy chain, TR109 light chain, TR92 heavy chain, ... | 著者 | Akiba, H, Fujita, J, Ise, T, Nishiyama, K, Miyata, T, Kato, T, Namba, K, Ohno, H, Kamada, H, Nagata, S, Tsumoto, K. | 登録日 | 2022-11-29 | 公開日 | 2023-10-04 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection. Commun Biol, 6, 2023
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8GYE
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8DS5
| X-ray structure of the MK5890 Fab - CD27 antibody-antigen complex | 分子名称: | CADMIUM ION, CD27 antigen, MK-5890 Fab heavy chain, ... | 著者 | Fischmann, T.O. | 登録日 | 2022-07-21 | 公開日 | 2022-09-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.926 Å) | 主引用文献 | Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy. J Immunother Cancer, 10, 2022
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8DPX
| Preligand association structure of DR5 | 分子名称: | Tumor necrosis factor receptor superfamily member 10B | 著者 | Du, G, Zhao, L, Chou, J.J. | 登録日 | 2022-07-17 | 公開日 | 2023-02-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell Res., 33, 2023
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8AG1
| Crystal structure of a novel OX40 antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Novel OX40 antibody heavy chain, Novel OX40 antibody light chain, ... | 著者 | Gao, H, Zhou, A. | 登録日 | 2022-07-19 | 公開日 | 2023-07-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.303 Å) | 主引用文献 | Structural Basis of a Novel Agonistic Anti-OX40 Antibody. Biomolecules, 12, 2022
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7YXU
| Crystal structure of agonistic antibody 1618 fab domain bound to human 4-1BB. | 分子名称: | MANGANESE (II) ION, Tumor necrosis factor receptor superfamily member 9, heavy chain of Fab, ... | 著者 | Hakansson, M, Rose, N, Petersson, J, Enell Smith, K, Thorolfsson, M, von Schantz, L. | 登録日 | 2022-02-16 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies. Mol.Cancer Ther., 22, 2023
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7YK4
| ox40-antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor receptor superfamily member 4, antibody-H, ... | 著者 | Zhou, A. | 登録日 | 2022-07-21 | 公開日 | 2023-08-09 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Basis of a Novel Agonistic Anti-OX40 Antibody. Biomolecules, 12, 2022
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7P3I
| Crystal structure of human CD40/TNFRSF5 in complex with the anti-CD40 DARPin protein | 分子名称: | Darpin, SODIUM ION, Tumor necrosis factor receptor superfamily member 5 | 著者 | Malvezzi, F, Mangold, S, Hospodarsch, T, Reichen, C, Iss, C, Lammens, A, Krapp, S, Domke, C. | 登録日 | 2021-07-07 | 公開日 | 2022-04-06 | 最終更新日 | 2022-05-11 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor Regression. Cancer Immunol Res, 10, 2022
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7MSJ
| The crystal structure of mouse HVEM | 分子名称: | SULFATE ION, Tumor necrosis factor receptor superfamily member 14 | 著者 | Liu, W, Ramagopal, U, Garrett-Thompson, S.C, Fedorov, E, Bonanno, J.B, Almo, S.C. | 登録日 | 2021-05-11 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160. J.Exp.Med., 218, 2021
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7MSG
| The crystal structure of LIGHT in complex with HVEM and CD160 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD160 antigen, soluble form,Tumor necrosis factor receptor superfamily member 14, ... | 著者 | Liu, W, Ramagopal, U, Garrett-Thompson, S.C, Fedorov, E, Bonanno, J.B, Almo, S.C. | 登録日 | 2021-05-11 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160. J.Exp.Med., 218, 2021
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7KX0
| Crystal structure of the CD27:CD70 co-stimulatory complex | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, ... | 著者 | Maben, Z, Liu, W, Mosyak, L, Chaparro-Riggers, J. | 登録日 | 2020-12-02 | 公開日 | 2021-09-08 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex. J.Biol.Chem., 297, 2021
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7KPB
| Human TNF-alpha TNFR1 complex bound to conformationally selective antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(1-{[2-(difluoromethoxy)phenyl]methyl}-2-{[3-(2-oxopyrrolidin-1-yl)phenoxy]methyl}-1H-benzimidazol-6-yl)pyridin-2(1H)-one, Fab1974 - Heavy Chain, ... | 著者 | Fox III, D, Conrady, D.G, Lowe, M, Ceska, T. | 登録日 | 2020-11-10 | 公開日 | 2021-01-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF Nat Commun, 12, 2021
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7KP8
| asymmetric mTNF-alpha hTNFR1 complex | 分子名称: | 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole, Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A | 著者 | Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T. | 登録日 | 2020-11-10 | 公開日 | 2021-01-13 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. Nat Commun, 12, 2021
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7KP7
| asymmetric mTNF-alpha hTNFR1 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tumor necrosis factor, ... | 著者 | Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T. | 登録日 | 2020-11-10 | 公開日 | 2021-01-13 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. Nat Commun, 12, 2021
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7D4B
| Crystal structure of 4-1BB in complex with a VHH | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Wang, C. | 登録日 | 2020-09-23 | 公開日 | 2021-07-14 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | 主引用文献 | Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer, 9, 2021
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6Y8K
| Crystal structure of CD137 in complex with the cyclic peptide BCY10916 | 分子名称: | 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Upadhyaya, P, Kublin, J, Dods, R, Kristensson, J, Lahdenranta, J, Kleyman, M, Repash, E, Ma, J, Mudd, G, Van Rietschoten, K, Haines, E, Harrison, H, Beswick, P, Chen, L, McDonnell, K, Battula, S, Hurov, K, Keen, N. | 登録日 | 2020-03-05 | 公開日 | 2021-02-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | 主引用文献 | Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist. J Immunother Cancer, 9, 2021
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6T3J
| Dual Epitope Targeting by Anti-DR5 Antibodies | 分子名称: | IgG1-hDR5-01-Heavy Chain, IgG1-hDR5-01-Light Chain, IgG1-hDR5-05-Heavy Chain, ... | 著者 | Tauchert, M.J, Augustin, M, Krapp, S, Overdijk, M.B, Breij, E.C.W, Hibbert, R.G. | 登録日 | 2019-10-11 | 公開日 | 2020-09-16 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism. Mol.Cancer Ther., 19, 2020
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6PE9
| Crystal Structure of CD40 complexed to FAB516 | 分子名称: | FAB Heavy chain, FAB Light chain, SULFATE ION, ... | 著者 | Argiriadi, M.A. | 登録日 | 2019-06-20 | 公開日 | 2019-08-14 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | 主引用文献 | CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches. BMC Mol Cell Biol, 20, 2019
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6PE8
| Crystal structure of CD40/ABBV-323 FAB complex | 分子名称: | FAB Heavy chain, FAB Light chain, SULFATE ION, ... | 著者 | Argiriadi, M.A. | 登録日 | 2019-06-20 | 公開日 | 2019-08-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches. BMC Mol Cell Biol, 20, 2019
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6OKN
| OX40R (TNFRSF4) bound to Fab 1A7 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Fab 1A7 heavy chain, Fab 1A7 light chain, ... | 著者 | Ultsch, M.H, Boenig, G, Harris, S.F. | 登録日 | 2019-04-14 | 公開日 | 2019-07-10 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members. Mabs, 11, 2019
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6OKM
| Human OX40R (TNFRSF4) bound to Fab 3C8 | 分子名称: | Fab 3C8 Heavy Chain, Fab 3C8 light chain, Tumor necrosis factor receptor superfamily member 4 | 著者 | Boenig, G, Ultsch, M.H, Harris, S.F. | 登録日 | 2019-04-14 | 公開日 | 2019-08-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members. Mabs, 11, 2019
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