7MSG

The crystal structure of LIGHT in complex with HVEM and CD160

Summary for 7MSG

Entry DOI	10.2210/pdb7msg/pdb
Descriptor	Tumor necrosis factor ligand superfamily member 14, membrane form, CD160 antigen, soluble form,Tumor necrosis factor receptor superfamily member 14, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	immunity, n-glycosylation, membrane, secreted protein, cytokine, jelly-roll fold, cysteine rich domain, signaling, cell membrane, secreted, immune system, immunoglobulin superfamily, tnf
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	136542.53
Authors	Liu, W.,Ramagopal, U.,Garrett-Thompson, S.C.,Fedorov, E.,Bonanno, J.B.,Almo, S.C. (deposition date: 2021-05-11, release date: 2021-10-27, Last modification date: 2023-10-18)
Primary citation	Liu, W.,Chou, T.F.,Garrett-Thomson, S.C.,Seo, G.Y.,Fedorov, E.,Ramagopal, U.A.,Bonanno, J.B.,Wang, Q.,Kim, K.,Garforth, S.J.,Kakugawa, K.,Cheroutre, H.,Kronenberg, M.,Almo, S.C. HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160. J.Exp.Med., 218:-, 2021 Cited by PubMed: 34709351 DOI: 10.1084/jem.20211112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation