7KP7

asymmetric mTNF-alpha hTNFR1 complex

Summary for 7KP7

• Entry DOI: 10.2210/pdb7kp7/pdb
• Descriptor: Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A, SULFATE ION, ... (5 entities in total)
• Functional Keywords: tumour necrosis factor alpha, tnf, receptor, tnfr1, asymmetric, protein-protein inhibitor, cytokine
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 101811.19

Authors

Arakaki, T.L.,Fox III, D.,Edwards, T.E.,Foley, A.,Ceska, T. (deposition date: 2020-11-10, release date: 2021-01-13, Last modification date: 2024-04-03)

• Primary citation: McMillan, D.,Martinez-Fleites, C.,Porter, J.,Fox 3rd, D.,Davis, R.,Mori, P.,Ceska, T.,Carrington, B.,Lawson, A.,Bourne, T.,O'Connell, J.; Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.; Nat Commun, 12:582-582, 2021; PubMed: 33495441; DOI: 10.1038/s41467-020-20828-3

Experimental method

X-RAY DIFFRACTION (2.65 Å)