7KP7
asymmetric mTNF-alpha hTNFR1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (B, A, C) | Tumor necrosis factor | polymer | 148 | 16411.6 | 3 | UniProt (P06804) Pfam (PF00229) | Mus musculus (Mouse) | Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a |
| 2 | D, E, F (E, D, F) | Tumor necrosis factor receptor superfamily member 1A | polymer | 144 | 16196.2 | 3 | UniProt (P19438) Pfam (PF00020) | Homo sapiens (Human) | Tumor necrosis factor receptor 1,TNF-R1,Tumor necrosis factor receptor type I,TNFR-I,p55,p60 |
| 3 | AA, BA, CA, DA, EA... (D, B, F, A, C...) | SULFATE ION | non-polymer | 96.1 | 30 | Chemie (SO4) | |||
| 4 | FA, GA, OA, Y, Z (D, F, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 5 | PA, QA, RA, SA, TA... (B, A, C, E, D...) | water | water | 18.0 | 225 | Chemie (HOH) |
Sequence modifications
E, D, F: 13 - 155 (UniProt: P19438)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| Asp 25 | Asn 54 | engineered mutation |
| Ser 153 | Cys 182 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 97823.3 | |
| Non-Polymers* | Number of molecules | 35 |
| Total formula weight | 3987.9 | |
| All* | Total formula weight | 101811.2 |
