7KP7

asymmetric mTNF-alpha hTNFR1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
C	0005164	molecular_function	tumor necrosis factor receptor binding
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane
D	0005031	molecular_function	tumor necrosis factor receptor activity
D	0006693	biological_process	prostaglandin metabolic process
D	0006954	biological_process	inflammatory response
D	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
E	0005031	molecular_function	tumor necrosis factor receptor activity
E	0006693	biological_process	prostaglandin metabolic process
E	0006954	biological_process	inflammatory response
E	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
F	0005031	molecular_function	tumor necrosis factor receptor activity
F	0006693	biological_process	prostaglandin metabolic process
F	0006954	biological_process	inflammatory response
F	0033209	biological_process	tumor necrosis factor-mediated signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00251
Number of Residues	17
Details	THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPaDGLYLVysQVlF

Chain	Residue	Details
B	LEU49-PHE65

site_id	PS00652
Number of Residues	38
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. CpqgkyiHpqdnsi....C..Ctk.Chkgtylynd..Cpgpgq.DTDC

site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. CtChaGFflrene..C

Chain	Residue	Details
E	CYS137-CYS150

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255