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7KPB

Human TNF-alpha TNFR1 complex bound to conformationally selective antibody

Summary for 7KPB
Entry DOI10.2210/pdb7kpb/pdb
DescriptorTumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A, Fab1974 - Light Chain, ... (8 entities in total)
Functional Keywordstumour necrosis factor alpha, tnf, asymmetric, protein-protein inhibitor, cytokine, fragment antibody, fab, cytokine-immune system complex, cytokine/immune system
Biological sourceHomo sapiens (Human)
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Total number of polymer chains7
Total formula weight134088.09
Authors
Fox III, D.,Conrady, D.G.,Lowe, M.,Ceska, T. (deposition date: 2020-11-10, release date: 2021-01-13, Last modification date: 2023-05-24)
Primary citationLightwood, D.J.,Munro, R.J.,Porter, J.,McMillan, D.,Carrington, B.,Turner, A.,Scott-Tucker, A.,Hickford, E.S.,Schmidt, A.,Fox III, D.,Maloney, A.,Ceska, T.,Bourne, T.,O'Connell, J.,Lawson, A.D.G.
A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF
Nat Commun, 12:583-583, 2021
Cited by
PubMed: 33495445
DOI: 10.1038/s41467-020-20825-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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