7KPB
Human TNF-alpha TNFR1 complex bound to conformationally selective antibody
Summary for 7KPB
Entry DOI | 10.2210/pdb7kpb/pdb |
Descriptor | Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A, Fab1974 - Light Chain, ... (8 entities in total) |
Functional Keywords | tumour necrosis factor alpha, tnf, asymmetric, protein-protein inhibitor, cytokine, fragment antibody, fab, cytokine-immune system complex, cytokine/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 7 |
Total formula weight | 134088.09 |
Authors | Fox III, D.,Conrady, D.G.,Lowe, M.,Ceska, T. (deposition date: 2020-11-10, release date: 2021-01-13, Last modification date: 2023-05-24) |
Primary citation | Lightwood, D.J.,Munro, R.J.,Porter, J.,McMillan, D.,Carrington, B.,Turner, A.,Scott-Tucker, A.,Hickford, E.S.,Schmidt, A.,Fox III, D.,Maloney, A.,Ceska, T.,Bourne, T.,O'Connell, J.,Lawson, A.D.G. A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF Nat Commun, 12:583-583, 2021 Cited by PubMed: 33495445DOI: 10.1038/s41467-020-20825-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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