7KPB
Human TNF-alpha TNFR1 complex bound to conformationally selective antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Tumor necrosis factor | polymer | 158 | 17457.7 | 3 | UniProt (P01375) Pfam (PF00229) | Homo sapiens (Human) | Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a |
| 2 | D, E (F, E) | Tumor necrosis factor receptor superfamily member 1A | polymer | 144 | 16196.2 | 2 | UniProt (P19438) Pfam (PF00020) | Homo sapiens (Human) | Tumor necrosis factor receptor 1,TNF-R1,Tumor necrosis factor receptor type I,TNFR-I,p55,p60 |
| 3 | F (L) | Fab1974 - Light Chain | polymer | 214 | 23649.2 | 1 | Mus musculus | ||
| 4 | G (H) | Fab1974 - Heavy Chain | polymer | 223 | 24066.8 | 1 | Mus musculus | ||
| 5 | H, I, J, L, M... (A, B, F, E, L) | GLYCEROL | non-polymer | 92.1 | 9 | Chemie (GOL) | |||
| 6 | K (C) | 5-(1-{[2-(difluoromethoxy)phenyl]methyl}-2-{[3-(2-oxopyrrolidin-1-yl)phenoxy]methyl}-1H-benzimidazol-6-yl)pyridin-2(1H)-one | non-polymer | 556.6 | 1 | Chemie (D84) | |||
| 7 | O (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | S, T, U, V, W... (A, B, C, F, E...) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 157 (UniProt: P01375)
F, E: 13 - 155 (UniProt: P19438)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| Asp 25 | Asn 54 | engineered mutation |
| Ser 153 | Cys 182 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 132481.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1606.6 | |
| All* | Total formula weight | 134088.1 |
