7KPB
Human TNF-alpha TNFR1 complex bound to conformationally selective antibody
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005164 | molecular_function | tumor necrosis factor receptor binding |
A | 0006955 | biological_process | immune response |
A | 0016020 | cellular_component | membrane |
B | 0005164 | molecular_function | tumor necrosis factor receptor binding |
B | 0006955 | biological_process | immune response |
B | 0016020 | cellular_component | membrane |
C | 0005164 | molecular_function | tumor necrosis factor receptor binding |
C | 0006955 | biological_process | immune response |
C | 0016020 | cellular_component | membrane |
E | 0005031 | molecular_function | tumor necrosis factor receptor activity |
E | 0006693 | biological_process | prostaglandin metabolic process |
E | 0006954 | biological_process | inflammatory response |
E | 0033209 | biological_process | tumor necrosis factor-mediated signaling pathway |
F | 0005031 | molecular_function | tumor necrosis factor receptor activity |
F | 0006693 | biological_process | prostaglandin metabolic process |
F | 0006954 | biological_process | inflammatory response |
F | 0033209 | biological_process | tumor necrosis factor-mediated signaling pathway |
Functional Information from PROSITE/UniProt
site_id | PS00251 |
Number of Residues | 17 |
Details | THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF |
Chain | Residue | Details |
A | LEU48-PHE64 |
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
Chain | Residue | Details |
L | TYR192-HIS198 |
site_id | PS00652 |
Number of Residues | 38 |
Details | TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. CpqgkyiHpqdnsi....C..Ctk.Chkgtylynd..Cpgpgq.DTDC |
Chain | Residue | Details |
F | CYS15-CYS52 | |
F | CYS55-CYS96 | |
F | CYS96-CYS137 |
site_id | PS01186 |
Number of Residues | 14 |
Details | EGF_2 EGF-like domain signature 2. CtChaGFflrene..C |
Chain | Residue | Details |
F | CYS137-CYS150 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
F | ASP25 | |
F | ASN116 | |
F | ASN122 | |
E | ASP25 | |
E | ASN116 | |
E | ASN122 |