9NSE
| BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE, ETHYL-ISOSELENOUREA COMPLEX | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, CACODYLIC ACID, ... | 著者 | Li, H, Raman, C.S, Martasek, P, Kral, V, Masters, B.S.S, Poulos, T.L. | 登録日 | 1999-01-13 | 公開日 | 2000-10-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas. J.Inorg.Biochem., 81, 2000
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9LDT
| DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK | 分子名称: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... | 著者 | Dunn, C.R, Holbrook, J.J, Muirhead, H. | 登録日 | 1991-11-26 | 公開日 | 1993-10-31 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Philos.Trans.R.Soc.London,Ser.B, 332, 1991
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9LDB
| DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK | 分子名称: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... | 著者 | Dunn, C.R, Holbrook, J.J, Muirhead, H. | 登録日 | 1991-11-26 | 公開日 | 1993-10-31 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Philos.Trans.R.Soc.London,Ser.B, 332, 1991
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9F40
| Crystal structure of the NTD domain from S. cerevisia Niemann-Pick type C protein NCR1 with ergosterol bound | 分子名称: | ACETONITRILE, DI(HYDROXYETHYL)ETHER, ERGOSTEROL, ... | 著者 | Nel, L, Olesen, E, Frain, K.M, Pedersen, B.P. | 登録日 | 2024-04-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C 1-related protein To Be Published
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9EO8
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9EO5
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9EO2
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9ENZ
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9BJU
| Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5 | 分子名称: | 1,2-ETHANEDIOL, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ACETATE ION, ... | 著者 | Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A. | 登録日 | 2024-04-25 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Potency-enhanced peptidomimetic VHL ligands with improved oral bioavailability To Be Published
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9B8E
| Structure of S-nitrosylated Legionella pneumophila Ceg10. | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | 著者 | Tomchick, D.R, Heisler, D.B, Alto, N.M. | 登録日 | 2024-03-29 | 公開日 | 2024-04-10 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery. Plos Pathog., 20, 2024
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9B3P
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9AY7
| Crystal structure of CRAF/MEK1 complex with NST-628 and inactive RAF | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-07 | 公開日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers. Cancer Discov, 2024
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8YYO
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8YYN
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8YUV
| Cryo-EM structure of the immepip-bound H3R-Gi complex | 分子名称: | 4-(1H-imidazol-5-ylmethyl)piperidine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | 登録日 | 2024-03-27 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 2024
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8YUU
| Cryo-EM structure of the histamine-bound H3R-Gi complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | 登録日 | 2024-03-27 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 2024
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8YTQ
| The structure of apoCopC from Thioalkalivibrio paradoxus | 分子名称: | ACETATE ION, COPPER (II) ION, CopC domain-containing protein, ... | 著者 | Kulikova, O.G, Solovieva, A.Y, Varfolomeeva, L.A, Dergousova, N.I, Boyko, K.M, Tikhonova, T.V, Popov, V.O. | 登録日 | 2024-03-26 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The structure of apoCopC from Thioalkalivibrio paradoxus To Be Published
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8YTI
| Crystal Structure of Nucleosome-H1x Linker Histone Assembly (sticky-169a DNA fragment) | 分子名称: | CALCIUM ION, CHLORIDE ION, DNA (169-MER), ... | 著者 | Adhireksan, Z, Qiuye, B, Padavattan, S, Davey, C.A. | 登録日 | 2024-03-26 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Linker Histones Associate Heterogeneously with Nucleosomes in the Condensed State To Be Published
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8YRU
| Crystal structure of D-amino acid transaminase from Haliscomenobacter hydrossis (apo form) after 15 sec of soaking with phenylhydrazine | 分子名称: | ACETATE ION, Aminotransferase class IV, [6-methyl-5-oxidanyl-4-[(2-phenylhydrazinyl)methyl]pyridin-3-yl]methyl dihydrogen phosphate | 著者 | Matyuta, I.O, Bakunova, A.K, Minyaev, M.E, Popov, V.O, Boyko, K.M. | 登録日 | 2024-03-21 | 公開日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of D-amino acid transaminase from Haliscomenobacter hydrossis (apo form) after 15 sec of soaking with phenylhydrazine To Be Published
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8YM7
| Crystal structure of Lysine Specific Demethylase 1 (LSD1) with JH-45 | 分子名称: | 4-[5-(4-azanylpiperidin-1-yl)-8-(4-methylphenyl)pyrido[3,4-b]pyrazin-7-yl]-2-fluoranyl-benzenecarbonitrile, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, ... | 著者 | Zhiyan, D, Danyan, C, Hong, J, Tongchao, L, Bing, X. | 登録日 | 2024-03-08 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Discovery of Novel LSD1 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease To Be Published
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8YJM
| Structure of human SPT16 MD-CTD and MCM2 HBD chaperoning a histone H3-H4 tetramer and a single chain H2B-H2A chimera | 分子名称: | DNA replication licensing factor MCM2, FACT complex subunit SPT16, Histone H2B 1/2/3/4/6,Histone H2A type 1-D, ... | 著者 | Gan, S.L, Yang, W.S, Xu, R.M. | 登録日 | 2024-03-02 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (4.15 Å) | 主引用文献 | Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2. Sci China Life Sci, 2024
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8YJF
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8YHR
| DHODH in complex with furocoumavirin | 分子名称: | 4-methyl-8-[(S)-oxidanyl(phenyl)methyl]-9-phenyl-furo[2,3-h]chromen-2-one, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | 著者 | Hara, K, Okumura, H, Nakahara, M, Sato, M, Hashimoto, H, Osada, H, Watanabe, K. | 登録日 | 2024-02-28 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin. Biochemistry, 63, 2024
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8YHL
| The Crystal Structure of Tgf-Beta Type I Receptor (Alk5) from Biortus | 分子名称: | 1,2-ETHANEDIOL, 2-fluoranyl-~{N}-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1~{H}-imidazol-2-yl]methyl]aniline, ACETATE ION, ... | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y. | 登録日 | 2024-02-28 | 公開日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | The Crystal Structure of Tgf-Beta Type I Receptor (Alk5) from Biortus To Be Published
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8Y1M
| Xylanase R from Bacillus sp. TAR-1 complexed with xylobiose. | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ... | 著者 | Nakamura, T, Kuwata, K, Takita, T, Mizutani, K, Mikami, B, Nakamura, S, Yasukawa, K. | 登録日 | 2024-01-25 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Activity-stability trade-off observed in variants at position 315 of the GH10 xylanase XynR. Sci Rep, 14, 2024
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