8YHR

DHODH in complex with furocoumavirin

This is a non-PDB format compatible entry.

Summary for 8YHR

• Entry DOI: 10.2210/pdb8yhr/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, OROTIC ACID, FLAVIN MONONUCLEOTIDE, ... (8 entities in total)
• Functional Keywords: dihydroorotate dehydrogenase, dhodh, oxidoreductase, inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43690.29

Authors

Hara, K.,Okumura, H.,Nakahara, M.,Sato, M.,Hashimoto, H.,Osada, H.,Watanabe, K. (deposition date: 2024-02-28, release date: 2024-05-22, Last modification date: 2024-06-05)

• Primary citation: Nakahara, M.,Watanabe, S.,Sato, M.,Okumura, H.,Kawatani, M.,Osada, H.,Hara, K.,Hashimoto, H.,Watanabe, K.; Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin.; Biochemistry, 63:1241-1245, 2024; PubMed: 38724483; DOI: 10.1021/acs.biochem.4c00120

Experimental method

X-RAY DIFFRACTION (1.7 Å)