PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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6EUV	Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787) 分子名称: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2 著者 Cusack, S, Lethier, M. 登録日 2017-10-31 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
6EUY	Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor 分子名称: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION 著者 Cusack, S, Gaudon, S. 登録日 2017-10-31 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
6EUW	Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor 分子名称: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2 著者 Cusack, S, Gaudon, S. 登録日 2017-10-31 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
3W3S	Crystal structure of A. aeolicus tRNASec in complex with M. kandleri SerRS 分子名称: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, PLATINUM (II) ION, SULFATE ION, ... 著者 Itoh, Y, Sekine, S, Yokoyama, S. 登録日 2012-12-27 公開日 2013-02-13 最終更新日 2013-08-07 実験手法 X-RAY DIFFRACTION (3.095 Å) 主引用文献 Tertiary structure of bacterial selenocysteine tRNA Nucleic Acids Res., 41, 2013
4AWM	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with (-)-epigallocatechin gallate from green tea 分子名称: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, MANGANESE (II) ION, POLYMERASE PA 著者 Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. 登録日 2012-06-04 公開日 2012-08-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
4AWK	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 1 分子名称: (2Z)-4-[(3S)-1-(benzylsulfonyl)-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA 著者 Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. 登録日 2012-06-04 公開日 2012-08-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
5FDD	Endonuclease inhibitor 1 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 分子名称: 5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde, MANGANESE (II) ION, Polymerase acidic protein,Polymerase acidic protein, ... 著者 Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Hoshino, T. 登録日 2015-12-16 公開日 2015-12-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.506 Å) 主引用文献 Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit Biochemistry, 55, 2016
4FWT	Complex structure of viral RNA polymerase form III 分子名称: CALCIUM ION, Elongation factor Ts, Elongation factor Tu, ... 著者 Takeshita, D, Tomita, K. 登録日 2012-07-02 公開日 2012-08-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Mechanism for template-independent terminal adenylation activity of Q beta replicase Structure, 20, 2012
5OMF	Closed, ternary structure of KOD DNA polymerase 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*C)-3'), ... 著者 Kropp, H.M, Betz, K, Wirth, J, Diederichs, K, Marx, A. 登録日 2017-07-31 公開日 2017-12-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.092 Å) 主引用文献 Crystal structures of ternary complexes of archaeal B-family DNA polymerases. PLoS ONE, 12, 2017
5FDG	Endonuclease inhibitor 3 bound to influenza strain H1N1 polymerase acidic subunit N-terminal region at pH 7.0 分子名称: (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, Polymerase acidic protein, ... 著者 Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Hoshino, T. 登録日 2015-12-16 公開日 2015-12-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit Biochemistry, 55, 2016
4GH9	Crystal structure of Marburg virus VP35 RNA binding domain 分子名称: ACETATE ION, Polymerase cofactor VP35 著者 Bale, S, Jean-Philippe, J, Bornholdt, Z.A, Kimberlin, C.K, Halfmann, P, Zandonatti, M.A, Kunert, J, Kroon, G.J.A, Kawaoka, Y, MacRae, I.J, Wilson, I.A, Saphire, E.O. 登録日 2012-08-07 公開日 2012-08-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism. Plos Pathog., 8, 2012
8R6U	Structure of the SFTSV L protein in a transcription-priming state without capped RNA [TRANSCRIPTION-PRIMING (in vitro)] 分子名称: MAGNESIUM ION, RNA (5'-R(P*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), RNA primer, ... 著者 Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. 登録日 2023-11-23 公開日 2024-04-24 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Structural snapshots of phenuivirus cap-snatching and transcription. Nucleic Acids Res., 52, 2024
4AWF	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with 2 4-dioxo-4-phenylbutanoic acid DPBA 分子名称: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MANGANESE (II) ION, POLYMERASE PA 著者 Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. 登録日 2012-06-03 公開日 2012-08-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
8E21	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023034 分子名称: 5-hydroxy-6-oxo-N-[2-(pyridin-4-yl)ethyl]-2-{[2-(trifluoromethyl)phenyl]methyl}-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2022-08-12 公開日 2022-09-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023034 To Be Published
8EDZ	The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ000986319 分子名称: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein, ... 著者 Cuypers, M.G, Slavish, J.P, Jayaraman, S, Rankovic, Z, White, S.W. 登録日 2022-09-06 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ000986319 To Be Published
4AVG	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 2 分子名称: (Z)-4-[4-[(4-chlorophenyl)methyl]-1-(cyclohexylmethyl)piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA 著者 Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. 登録日 2012-05-25 公開日 2012-08-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
3UPI	Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors 分子名称: (3S)-6-(2,5-difluorobenzyl)-3-methyl-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase 著者 Velazquez, F, Venkataraman, S, Lesburg, C.A, Duca, J.S, Rosenblum, S.B, Kozlowski, J.A, Njoroge, F.G. 登録日 2011-11-18 公開日 2012-01-25 最終更新日 2012-02-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors. Org.Lett., 14, 2012
4AWG	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 3 分子名称: (2Z)-4-[(3S)-1-benzyl-3-(4-chlorobenzyl)piperidin-3-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, POLYMERASE PA, ... 著者 Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. 登録日 2012-06-03 公開日 2012-08-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
3UPH	Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors 分子名称: 6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase 著者 Velazquez, F, Venkataraman, S, Lesburg, C.A, Duca, J.S, Rosenblum, S.B, Kozlowski, J.A, Njoroge, F.G. 登録日 2011-11-18 公開日 2012-01-25 最終更新日 2012-02-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors. Org.Lett., 14, 2012
8E1Q	The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023044 分子名称: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2022-08-11 公開日 2022-09-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023044 To Be Published
2WRM	Identification of Novel Allosteric Inhibitors of Hepatitis C Virus NS5B Polymerase Thumb Domain (Site II) by Structure-Based Design 分子名称: (3R)-3-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLIN-2-YL)HEXANOIC ACID, RNA-DIRECTED RNA POLYMERASE 著者 Di Marco, S. 登録日 2009-09-01 公開日 2010-09-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Identification of Novel Allosteric Inhibitors of Hepatitis C Virus Ns5B Polymerase Thumb Domain (Site II) by Structure-Based Design To be Published
4AWH	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with rUMP 分子名称: MANGANESE (II) ION, POLYMERASE PA, URIDINE-5'-MONOPHOSPHATE 著者 Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. 登録日 2012-06-03 公開日 2012-08-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012
6JHE	Crystal Structure of Bacillus subtilis SigW domain 4 in complexed with -35 element DNA 分子名称: DNA (5'-D(*AP*AP*AP*GP*GP*TP*TP*TP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*AP*AP*AP*CP*CP*TP*TP*T)-3'), ECF RNA polymerase sigma factor SigW 著者 Kwon, E, Devkota, S.R, Pathak, D, Dahal, P, Kim, D.Y. 登録日 2019-02-18 公開日 2020-01-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.101 Å) 主引用文献 Structural analysis of the recognition of the -35 promoter element by SigW from Bacillus subtilis. Plos One, 14, 2019
1ZZN	Crystal structure of a group I intron/two exon complex that includes all catalytic metal ion ligands. 分子名称: 197-MER, 5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*AP*GP*AP*CP*GP*GP*CP*C)-3', 5'-R(*CP*AP*(5MU))-3', ... 著者 Stahley, M.R, Strobel, S.A. 登録日 2005-06-14 公開日 2005-08-30 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.37 Å) 主引用文献 Structural evidence for a two-metal-ion mechanism of group I intron splicing. Science, 309, 2005
4AVQ	Influenza strain pH1N1 2009 polymerase subunit PA endonuclease 分子名称: MAGNESIUM ION, MANGANESE (II) ION, POLYMERASE PA 著者 Kowalinski, E, Zubieta, C, Wolkerstorfer, A, Szolar, O.H, Ruigrok, R.W, Cusack, S. 登録日 2012-05-29 公開日 2012-08-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase. Plos Pathog., 8, 2012

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