4AVG

Influenza strain pH1N1 2009 polymerase subunit PA endonuclease in complex with diketo compound 2

Summary for 4AVG

• Entry DOI: 10.2210/pdb4avg/pdb
• Related: 4AVL 4AVQ 4AWF 4AWG 4AWH 4AWK 4AWM
• Descriptor: POLYMERASE PA, (Z)-4-[4-[(4-chlorophenyl)methyl]-1-(cyclohexylmethyl)piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoic acid, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, hydrolase, manganese-dependent, hydrolase/inhibitor
• Biological source: INFLUENZA A VIRUS
• Total number of polymer chains: 4
• Total formula weight: 97876.44

Authors

Kowalinski, E.,Zubieta, C.,Wolkerstorfer, A.,Szolar, O.H.,Ruigrok, R.W.,Cusack, S. (deposition date: 2012-05-25, release date: 2012-08-22, Last modification date: 2023-12-20)

• Primary citation: Kowalinski, E.,Zubieta, C.,Wolkerstorfer, A.,Szolar, O.H.,Ruigrok, R.W.,Cusack, S.; Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza Ph1N1 (2009) Polymerase.; Plos Pathog., 8:2831-, 2012; PubMed: 22876177; DOI: 10.1371/JOURNAL.PPAT.1002831

Experimental method

X-RAY DIFFRACTION (2.2 Å)