PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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7OPL	CryoEM structure of DNA Polymerase alpha - primase bound to SARS CoV nsp1 分子名称: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ... 著者 Kilkenny, M.L, Pellegrini, L. 登録日 2021-06-01 公開日 2021-11-10 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.12 Å) 主引用文献 Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase alpha-primase. Protein Sci., 31, 2022
8GZQ	Cryo-EM structure of the NS5-NS3-SLA complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, Genome polyprotein, RNA, ... 著者 Osawa, T, Ehara, H, Sekine, S. 登録日 2022-09-27 公開日 2023-08-02 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
8GZP	Cryo-EM structure of the NS5-SLA complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ... 著者 Osawa, T, Ehara, H, Sekine, S. 登録日 2022-09-27 公開日 2023-08-02 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
4OAU	Complete human RNase L in complex with biological activators. 分子名称: 2-5A-dependent ribonuclease, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A. 登録日 2014-01-06 公開日 2014-03-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science, 343, 2014
3H2L	Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor 分子名称: N-{3-[(4aR,7aS)-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,7a-hexahydro-1H-cyclopenta[b]pyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, NS5B polymerase 著者 Han, Q, Showalter, R.E, Zhou, Q, Kissinger, C.R. 登録日 2009-04-14 公開日 2009-12-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
7NS2	Virion of Leishmania RNA virus 1 分子名称: Capsid protein 著者 Prochazkova, M, Grybchuk, D, Fuzik, T. 登録日 2021-03-05 公開日 2022-09-21 最終更新日 2022-11-23 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Virion structure of Leishmania RNA virus 1. Virology, 577, 2022
5DTO	Dengue virus full length NS5 complexed with viral Cap 0-RNA and SAH 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, ACETATE ION, MAGNESIUM ION, ... 著者 Zhao, Y, Soh, T.S, Lim, S.P, Chung, K.Y, Swaminathan, K, Vasudevan, S.G, Shi, P.-Y, Lescar, J, Luo, D. 登録日 2015-09-18 公開日 2015-11-25 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.603 Å) 主引用文献 Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5) Proc.Natl.Acad.Sci.USA, 112, 2015
5WL0	Co-crystal structure of Influenza A H3N2 PB2 (241-741) bound to VX-787 分子名称: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, Polymerase basic protein 2 著者 Ma, X, Shia, S. 登録日 2017-07-25 公開日 2017-09-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit. Sci Rep, 7, 2017
3VU7	Crystal structure of REV1-REV7-REV3 ternary complex 分子名称: DNA polymerase zeta catalytic subunit, DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B 著者 Kikuchi, S, Hara, K, Shimizu, T, Sato, M, Hashimoto, H. 登録日 2012-06-20 公開日 2012-08-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis of recruitment of DNA polymerase [zeta] by interaction between REV1 and REV7 proteins J.Biol.Chem., 287, 2012
3Q24	X-ray crystal structure of the N4 mini-VRNAP and P2_7a promoter transcription initiation complex with pppGpG and pyrophosphate: product complex 分子名称: DIHYDROGENPHOSPHATE ION, DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*AP*TP*CP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), GUANOSINE-5'-MONOPHOSPHATE, ... 著者 Gleghorn, M.L, Murakami, K.S. 登録日 2010-12-19 公開日 2011-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides. Proc.Natl.Acad.Sci.USA, 108, 2011
4R71	Structure of the Qbeta holoenzyme complex in the P1211 crystal form 分子名称: 30S ribosomal protein S1, Elongation factor Ts, Elongation factor Tu, ... 著者 Gytz, H, Seweryn, P, Kutlubaeva, Z, Chetverin, A.B, Brodersen, D.E, Knudsen, C.R. 登録日 2014-08-26 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural basis for RNA-genome recognition during bacteriophage Q beta replication. Nucleic Acids Res., 43, 2015
8FYH	G4 RNA-mediated PRC2 dimer 分子名称: G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ... 著者 Song, J, Kasinath, V. 登録日 2023-01-26 公開日 2023-10-04 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science, 381, 2023
2W69	Influenza polymerase fragment 分子名称: MANGANESE (II) ION, POLYMERASE ACIDIC PROTEIN, SULFATE ION 著者 Dias, A, Bouvier, D, Crepin, T, McCarthy, A.A, Hart, D.J, Baudin, F, Cusack, S, Ruigrok, R.W.H. 登録日 2008-12-17 公開日 2009-02-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The CAP-Snatching Endonuclease of Influenza Virus Polymerase Resides in the Pa Subunit Nature, 458, 2009
8GWM	SARS-CoV-2 E-RTC bound with MMP-nsp9 and GMPPNP 分子名称: 2'-deoxy-2'-fluoro-2'-methyluridine 5'-(trihydrogen diphosphate), Helicase, Non-structural protein 7, ... 著者 Yan, L.M, Rao, Z.H, Lou, Z.Y. 登録日 2022-09-17 公開日 2024-02-28 実験手法 ELECTRON MICROSCOPY (2.64 Å) 主引用文献 A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
6XQB	SARS-CoV-2 RdRp/RNA complex 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Liu, B, Shi, W, Yang, Y. 登録日 2020-07-09 公開日 2020-07-29 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution To Be Published
3Q22	X-ray crystal structure of the N4 mini-VRNAP and P2_7a promoter transcription initiation complex with GTP and Magnesium: substrate complex I 分子名称: DIHYDROGENPHOSPHATE ION, DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*AP*TP*CP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Gleghorn, M.L, Murakami, K.S. 登録日 2010-12-19 公開日 2011-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides. Proc.Natl.Acad.Sci.USA, 108, 2011
7XW2	Cryo-EM structure of human DICER-pre-miRNA in a dicing state 分子名称: CALCIUM ION, Endoribonuclease Dicer, RNA (73-MER) 著者 Lee, H, Roh, S.-H. 登録日 2022-05-26 公開日 2023-03-08 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Structure of the human DICER-pre-miRNA complex in a dicing state. Nature, 615, 2023
3Q23	X-ray crystal structure of the N4 mini-VRNAP and P2_7a promoter transcription initiation complex with GMPCPP and Manganese: sustrate complex II 分子名称: DIHYDROGENPHOSPHATE ION, DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*AP*TP*CP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), MANGANESE (II) ION, ... 著者 Gleghorn, M.L, Murakami, K.S. 登録日 2010-12-19 公開日 2011-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides. Proc.Natl.Acad.Sci.USA, 108, 2011
4EO8	HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres 分子名称: 5-(3,3-dimethylbut-1-yn-1-yl)-3-{2,2-dimethyl-1-[(trans-4-methylcyclohexyl)carbonyl]hydrazinyl}thiophene-2-carboxylic acid, RNA-directed RNA polymerase 著者 Appleby, T.C, Canales, E, Watkins, W.J. 登録日 2012-04-13 公開日 2012-06-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.798 Å) 主引用文献 Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
3Q0A	X-ray crystal structure of the transcription initiation complex of the N4 mini-vRNAP with P2 promoter: Mismatch complex 分子名称: DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*A*GP*TP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ... 著者 Murakami, K.S. 登録日 2010-12-15 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides. Proc.Natl.Acad.Sci.USA, 108, 2011
4EO6	HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres 分子名称: 5-(3,3-dimethylbut-1-yn-1-yl)-3-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}thiophene-2-carboxylic acid, RNA-directed RNA polymerase 著者 Appleby, T.C, Canales, E, Watkins, W.J. 登録日 2012-04-13 公開日 2012-06-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.791 Å) 主引用文献 Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
2HWH	HCV NS5B allosteric inhibitor complex 分子名称: 4-METHYL-N-{(5E)-5-[(5-METHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}BENZENESULFONAMIDE, RNA-directed RNA polymerase (NS5B) (p68) 著者 Yao, N. 登録日 2006-08-01 公開日 2006-11-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
2BPG	STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*GP*CP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*CP*GP*CP*CP*G)-3'), ... 著者 Pelletier, H, Sawaya, M.R, Kumar, A, Wilson, S.H, Kraut, J. 登録日 1994-05-19 公開日 1994-08-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP. Science, 264, 1994
2BPF	STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*GP*CP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*CP*GP*CP*CP*G)-3'), ... 著者 Pelletier, H, Sawaya, M.R, Kumar, A, Wilson, S.H, Kraut, J. 登録日 1994-05-19 公開日 1994-12-14 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP. Science, 264, 1994
8R6Y	Structure of the SFTSV L protein stalled in a transcription-specific early elongation state with bound capped RNA [TRANSCRIPTION-EARLY-ELONGATION] 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(*(M7G)*AP*AP*A)-3'), ... 著者 Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. 登録日 2023-11-23 公開日 2024-04-24 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural snapshots of phenuivirus cap-snatching and transcription. Nucleic Acids Res., 52, 2024

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