5WL0

Co-crystal structure of Influenza A H3N2 PB2 (241-741) bound to VX-787

Summary for 5WL0

• Entry DOI: 10.2210/pdb5wl0/pdb
• Descriptor: Polymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: polymerase basic protein 2, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Influenza A virus (strain A/Udorn/307/1972 H3N2)
• Cellular location: Virion : Q67296
• Total number of polymer chains: 1
• Total formula weight: 58090.48

Authors

Ma, X.,Shia, S. (deposition date: 2017-07-25, release date: 2017-09-06, Last modification date: 2023-10-04)

• Primary citation: Ma, X.,Xie, L.,Wartchow, C.,Warne, R.,Xu, Y.,Rivkin, A.,Tully, D.,Shia, S.,Uehara, K.,Baldwin, D.M.,Muiru, G.,Zhong, W.,Zaror, I.,Bussiere, D.E.,Leonard, V.H.J.; Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit.; Sci Rep, 7:9385-9385, 2017; PubMed: 28839261; DOI: 10.1038/s41598-017-09538-x

Experimental method

X-RAY DIFFRACTION (2.4 Å)