5WL0
Co-crystal structure of Influenza A H3N2 PB2 (241-741) bound to VX-787
Summary for 5WL0
Entry DOI | 10.2210/pdb5wl0/pdb |
Descriptor | Polymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... (4 entities in total) |
Functional Keywords | polymerase basic protein 2, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Influenza A virus (strain A/Udorn/307/1972 H3N2) |
Cellular location | Virion : Q67296 |
Total number of polymer chains | 1 |
Total formula weight | 58090.48 |
Authors | |
Primary citation | Ma, X.,Xie, L.,Wartchow, C.,Warne, R.,Xu, Y.,Rivkin, A.,Tully, D.,Shia, S.,Uehara, K.,Baldwin, D.M.,Muiru, G.,Zhong, W.,Zaror, I.,Bussiere, D.E.,Leonard, V.H.J. Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit. Sci Rep, 7:9385-9385, 2017 Cited by PubMed: 28839261DOI: 10.1038/s41598-017-09538-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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