5WL0
Co-crystal structure of Influenza A H3N2 PB2 (241-741) bound to VX-787
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Polymerase basic protein 2 | polymer | 510 | 57585.0 | 1 | UniProt (Q67296) Pfam (PF20950) Pfam (PF00604) Pfam (PF20951) Pfam (PF20952) In PDB | Influenza A virus (strain A/Udorn/307/1972 H3N2) | RNA-directed RNA polymerase subunit P3 |
| 2 | A | (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid | non-polymer | 399.4 | 1 | Chemie (21G) | |||
| 3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A: 241 - 741 (UniProt: Q67296)
| PDB | External Database | Details |
|---|---|---|
| Met 240 | - | initiating methionine |
| Ile 255 | Val 255 | conflict |
| Ser 271 | Ala 271 | conflict |
| Gln 288 | Leu 288 | conflict |
| His 522 | Gln 522 | conflict |
| Val 742 | - | expression tag |
| Asp 743 | - | expression tag |
| His 744 | - | expression tag |
| His 745 | - | expression tag |
| His 746 | - | expression tag |
| His 747 | - | expression tag |
| His 748 | - | expression tag |
| His 749 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 57585.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 505.5 | |
| All* | Total formula weight | 58090.5 |
