PDB: 30867 件ウェブページステータス検索Chemie searchBIRD

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6GG9	Crystal structures of a short blue light photoreceptor protein PpSB1-LOV mutant (dark state) - R61H/R66I 分子名称: FLAVIN MONONUCLEOTIDE, Sensory box protein 著者 Roellen, K, Granzin, J, Batra-Safferling, R. 登録日 2018-05-03 公開日 2018-07-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Small-angle X-ray scattering study of the kinetics of light-dark transition in a LOV protein. PLoS ONE, 13, 2018
8BAW	X-ray structure of the CeuE Homologue from Geobacillus stearothermophilus - 5-LICAM siderophore analogue complex. 分子名称: FE (III) ION, N,N'-pentane-1,5-diylbis(2,3-dihydroxybenzamide), Siderophore ABC transporter substrate-binding protein 著者 Blagova, E.V, Miller, A, Booth, R, Dodson, E.J, Duhme-Klair, A.K, Wilson, K.S. 登録日 2022-10-12 公開日 2023-07-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.471 Å) 主引用文献 Thermostable homologues of the periplasmic siderophore-binding protein CeuE from Geobacillus stearothermophilus and Parageobacillus thermoglucosidasius. Acta Crystallogr D Struct Biol, 79, 2023
6ZG4	Structure of M1-StaR-T4L in complex with HTL0009936 at 2.35A 分子名称: Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1, OLEIC ACID, PHOSPHATE ION, ... 著者 Rucktooa, P, Cooke, R.M. 登録日 2020-06-18 公開日 2021-10-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. Cell, 184, 2021
6I0Q	Crystal structure of BTB domain of KCTD16 hexamer 分子名称: BTB/POZ domain-containing protein KCTD16 著者 Kasaragod, V.B, Sereikaite, V, Stromgaard, K, Schindelin, H. 登録日 2018-10-26 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Targeting the gamma-Aminobutyric Acid Type B (GABAB) Receptor Complex: Development of Inhibitors Targeting the K+Channel Tetramerization Domain (KCTD) Containing Proteins/GABABReceptor Protein-Protein Interaction. J.Med.Chem., 62, 2019
6BWH	Crystal structure of Mycoibacterium tuberculosis Rv2983 in complex with PEP 分子名称: 2-phospho-L-lactate guanylyltransferase, MAGNESIUM ION, PHOSPHOENOLPYRUVATE 著者 Bashiri, G, Jirgis, E.N.M, Baker, E.N. 登録日 2017-12-15 公開日 2018-12-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 A revised biosynthetic pathway for the cofactor F420in prokaryotes. Nat Commun, 10, 2019
7R60	BTK in complex with 18A 分子名称: 2-(4-phenoxyphenoxy)-5-[(3R)-1-(prop-2-enoyl)piperidin-3-yl]pyridine-3-carboxamide, Tyrosine-protein kinase BTK 著者 Gardberg, A. 登録日 2021-06-22 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity. Chemmedchem, 16, 2021
6ZGR	Crystal structure of a MFS transporter with bound 1-hydroxynaphthalene-2-carboxylic acid at 2.67 Angstroem resolution 分子名称: 1-hydroxynaphthalene-2-carboxylic acid, L-lactate transporter 著者 Kalbermatter, D, Bosshart, P, Bonetti, S, Fotiadis, D. 登録日 2020-06-19 公開日 2021-10-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 The making of a potent L-lactate transport inhibitor Commun Chem, 4, 2021
6KAK	Crystal structure of FKRP in complex with Mg ion 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fukutin-related protein, MAGNESIUM ION, ... 著者 Kuwabara, N. 登録日 2019-06-23 公開日 2020-01-15 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.056 Å) 主引用文献 Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy. Nat Commun, 11, 2020
6GGG	Mineralocorticoid receptor in complex with (s)-13 分子名称: 2-[(3~{S})-7-fluoranyl-6-(2-methylpropyl)-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide, CHLORIDE ION, Mineralocorticoid receptor, ... 著者 Edman, K, Aagaard, A, Tangefjord, S. 登録日 2018-05-03 公開日 2019-01-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection. J.Med.Chem., 62, 2019
7RFD	E. coli peptidyl-prolyl cis-trans isomerase, mutant Phe4Ala Phe27CF3-Phe/Phe98CF3-Phe 分子名称: Peptidyl-prolyl cis-trans isomerase 著者 Frkic, R.L, Otting, G, Jackson, C.J. 登録日 2021-07-14 公開日 2021-09-29 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Through-Space Scalar 19 F- 19 F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins. J.Am.Chem.Soc., 143, 2021
6ZGU	Crystal structure of a MFS transporter with bound 3-(2-methylphenyl)propanoic acid at 2.41 Angstroem resolution 分子名称: 3-(2-methylphenyl)propanoic acid, L-lactate transporter 著者 Kalbermatter, D, Bosshart, P, Bonetti, S, Fotiadis, D. 登録日 2020-06-19 公開日 2021-10-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 The making of a potent L-lactate transport inhibitor Commun Chem, 4, 2021
6KB8	X-ray structure of human PPARalpha ligand binding domain-GW7647 co-crystals obtained by cross-seeding 分子名称: 2-[(4-{2-[(4-cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor alpha 著者 Kamata, S, Suda, K, Saito, K, Oyama, T, Ishii, I. 登録日 2019-06-24 公開日 2020-11-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
6GGO	Crystal structure of Salmonella zinc metalloprotease effector GtgA 分子名称: Bacteriophage virulence determinant, CHLORIDE ION, ZINC ION 著者 Jennings, E, Esposito, D, Rittinger, K, Thurston, T. 登録日 2018-05-03 公開日 2018-08-29 最終更新日 2018-10-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-kappa B. J. Biol. Chem., 293, 2018
7JLR	Crystal structure of Bacillus subtilis UppS in complex with JPD447 分子名称: 7-(azepan-1-yl)-5-ethyl-3-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine, Isoprenyl transferase 著者 Workman, S.D, Strynadka, N.C.J. 登録日 2020-07-30 公開日 2021-08-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria. J.Med.Chem., 64, 2021
5G58	Crystal structure of A190T mutant of human hippocalcin AT 2.5 A resolution 分子名称: CALCIUM ION, Neuron-specific calcium-binding protein hippocalcin 著者 Antonyuk, S.V, Helassa, N, Lian, L.Y, Haynes, L.P, Burgoyne, R.D. 登録日 2016-05-22 公開日 2017-05-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Hum. Mol. Genet., 26, 2017
8R7D	Complex of rice blast (Magnaporthe oryzae) mutant effector protein PWL2-SNDE with the HMA domain of OsHIPP43 from rice (Oryza sativa) 分子名称: Os01g0507700 protein, Pwl2 protein 著者 Zdrzalek, R, Banfield, M.J. 登録日 2023-11-24 公開日 2024-01-31 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Bioengineering a plant NLR immune receptor with a robust binding interface toward a conserved fungal pathogen effector. Proc.Natl.Acad.Sci.USA, 121, 2024
6ZGT	Crystal structure of a MFS transporter with bound 2-naphthoic acid at 2.39 Angstroem resolution 分子名称: L-lactate transporter, naphthalene-2-carboxylic acid 著者 Kalbermatter, D, Bosshart, P, Bonetti, S, Fotiadis, D. 登録日 2020-06-19 公開日 2021-10-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 The making of a potent L-lactate transport inhibitor Commun Chem, 4, 2021
6R2I	Crystal structure of the SUN1-KASH5 6:6 complex 分子名称: KASH5, POTASSIUM ION, SUN domain-containing protein 1 著者 Gurusaran, M, Davies, O.R. 登録日 2019-03-18 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.541 Å) 主引用文献 A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies. Elife, 10, 2021
7R61	BTK in complex with 25A 分子名称: 5-{(3S)-1-[(Z)-iminomethyl]piperidin-3-yl}-2-(4-phenoxyphenoxy)pyridine-3-carboxamide, DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK 著者 Gardberg, A. 登録日 2021-06-22 公開日 2021-10-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity. Chemmedchem, 16, 2021
5T8Q	Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to aryl pyrrole fragment 17 分子名称: 1-[(2-chlorophenyl)methyl]pyrrole-2-carboxamide, Mitogen-activated protein kinase kinase kinase 14, SULFATE ION 著者 Smith, M.A, McEwan, P.A, Hymowitz, S.G. 登録日 2016-09-08 公開日 2017-01-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Structure-Based Design of Tricyclic NF-kappa B Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K). J. Med. Chem., 60, 2017
6ZGS	Crystal structure of a MFS transporter with bound 3-phenylpropanoic acid at 2.39 Angstroem resolution 分子名称: HYDROCINNAMIC ACID, L-lactate transporter 著者 Kalbermatter, D, Bosshart, P, Bonetti, S, Fotiadis, D. 登録日 2020-06-19 公開日 2021-10-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.151 Å) 主引用文献 The making of a potent L-lactate transport inhibitor Commun Chem, 4, 2021
6BWR	LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with nickel 分子名称: NICKEL (II) ION, Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein 著者 Fellner, M, Hausinger, R.P, Hu, J. 登録日 2017-12-15 公開日 2018-06-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase. J. Biol. Chem., 293, 2018
6Z01	DNA Topoisomerase 分子名称: CHLORIDE ION, DNA topoisomerase I 著者 Takahashi, T.S, Gadelle, D, Forterre, P, Mayer, C, Petrella, S. 登録日 2020-05-07 公開日 2021-11-17 最終更新日 2023-05-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states. Nat Commun, 13, 2022
5G3Y	Crystal structure of adenylate kinase ancestor 1 with Zn and ADP bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENYLATE KINSE, ZINC ION 著者 Nguyen, V, Kutter, S, English, J, Kern, D. 登録日 2016-05-03 公開日 2016-12-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Evolutionary drivers of thermoadaptation in enzyme catalysis. Science, 355, 2017
6OSU	Crystal Structure of the D-alanyl-D-alanine carboxypeptidase DacD from Francisella tularensis 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, D-alanyl-D-alanine carboxypeptidase (Penicillin binding protein) family protein 著者 Kim, Y, Stogios, P, Skarina, T, Di, R, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2019-05-02 公開日 2019-05-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Crystal Structure of the D-alanyl-D-alanine carboxypeptidase DacD from Francisella tularensis To Be Published

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