4QYY
| Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State | Descriptor: | (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Deng, Y, Shipps, G.W, Cooper, A, English, J.M, Annis, D.A, Carr, D, Nan, Y, Wang, T, Zhu, Y.H, Chuang, C, Dayananth, P, Hruza, A.W, Xiao, L, Jin, W, Kirschmeier, P, Windsor, W.T, Samatar, A.A. | Deposit date: | 2014-07-26 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase. J.Med.Chem., 57, 2014
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5G3Y
| Crystal structure of adenylate kinase ancestor 1 with Zn and ADP bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENYLATE KINSE, ZINC ION | Authors: | Nguyen, V, Kutter, S, English, J, Kern, D. | Deposit date: | 2016-05-03 | Release date: | 2016-12-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Evolutionary drivers of thermoadaptation in enzyme catalysis. Science, 355, 2017
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5G40
| Crystal structure of adenylate kinase ancestor 4 with Zn and AMP-ADP bound | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ADENYLATE KINSE, ... | Authors: | Nguyen, V, Kutter, S, English, J, Kern, D. | Deposit date: | 2016-05-03 | Release date: | 2016-12-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Evolutionary drivers of thermoadaptation in enzyme catalysis. Science, 355, 2017
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5G3Z
| Crystal structure of adenylate kinase ancestor 3 with Zn, Mg and Ap5A bound | Descriptor: | ADENYLATE KINSE, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | Authors: | Nguyen, V, Kutter, S, English, J, Kern, D. | Deposit date: | 2016-05-03 | Release date: | 2016-12-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Evolutionary drivers of thermoadaptation in enzyme catalysis. Science, 355, 2017
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5G41
| Crystal structure of adenylate kinase ancestor 4 with Zn, Mg and Ap5A bound | Descriptor: | ADENYLATE KINSE, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | Authors: | Nguyen, V, Kutter, S, English, J, Kern, D. | Deposit date: | 2016-05-03 | Release date: | 2016-12-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Evolutionary drivers of thermoadaptation in enzyme catalysis. Science, 355, 2017
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