6ZG4
Structure of M1-StaR-T4L in complex with HTL0009936 at 2.35A
Summary for 6ZG4
Entry DOI | 10.2210/pdb6zg4/pdb |
Descriptor | Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1, ethyl (4~{S})-4-[4-[(1-methylcyclobutyl)carbamoyl]piperidin-1-yl]azepane-1-carboxylate, OLEIC ACID, ... (6 entities in total) |
Functional Keywords | gpcr, 7tm, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 55741.08 |
Authors | Rucktooa, P.,Cooke, R.M. (deposition date: 2020-06-18, release date: 2021-10-06, Last modification date: 2024-01-24) |
Primary citation | Brown, A.J.H.,Bradley, S.J.,Marshall, F.H.,Brown, G.A.,Bennett, K.A.,Brown, J.,Cansfield, J.E.,Cross, D.M.,de Graaf, C.,Hudson, B.D.,Dwomoh, L.,Dias, J.M.,Errey, J.C.,Hurrell, E.,Liptrot, J.,Mattedi, G.,Molloy, C.,Nathan, P.J.,Okrasa, K.,Osborne, G.,Patel, J.C.,Pickworth, M.,Robertson, N.,Shahabi, S.,Bundgaard, C.,Phillips, K.,Broad, L.M.,Goonawardena, A.V.,Morairty, S.R.,Browning, M.,Perini, F.,Dawson, G.R.,Deakin, J.F.W.,Smith, R.T.,Sexton, P.M.,Warneck, J.,Vinson, M.,Tasker, T.,Tehan, B.G.,Teobald, B.,Christopoulos, A.,Langmead, C.J.,Jazayeri, A.,Cooke, R.M.,Rucktooa, P.,Congreve, M.S.,Weir, M.,Tobin, A.B. From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. Cell, 184:5886-, 2021 Cited by PubMed: 34822784DOI: 10.1016/j.cell.2021.11.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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