7R61

BTK in complex with 25A

Summary for 7R61

• Entry DOI: 10.2210/pdb7r61/pdb
• Related: 7R60
• Descriptor: Tyrosine-protein kinase BTK, 5-{(3S)-1-[(Z)-iminomethyl]piperidin-3-yl}-2-(4-phenoxyphenoxy)pyridine-3-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: kinase, kinase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 32113.97

Authors

Gardberg, A. (deposition date: 2021-06-22, release date: 2021-10-06, Last modification date: 2023-10-18)

• Primary citation: Qiu, H.,Ali, Z.,Bowlan, J.,Caldwell, R.,Gardberg, A.,Glaser, N.,Goutopoulos, A.,Head, J.,Johnson, T.,Maurer, C.,Georgi, K.,Grenningloh, R.,Fang, Z.,Morandi, F.,Rohdich, F.,Schmidt, R.,Follis, A.V.,Sherer, B.; Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity.; Chemmedchem, 16:3653-3662, 2021; PubMed: 34582626; DOI: 10.1002/cmdc.202100453

Experimental method

X-RAY DIFFRACTION (1.52 Å)