7R60
BTK in complex with 18A
Summary for 7R60
Entry DOI | 10.2210/pdb7r60/pdb |
Descriptor | Tyrosine-protein kinase BTK, 2-(4-phenoxyphenoxy)-5-[(3R)-1-(prop-2-enoyl)piperidin-3-yl]pyridine-3-carboxamide (3 entities in total) |
Functional Keywords | kinase, kinase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32043.80 |
Authors | Gardberg, A. (deposition date: 2021-06-22, release date: 2021-10-06, Last modification date: 2023-10-18) |
Primary citation | Qiu, H.,Ali, Z.,Bowlan, J.,Caldwell, R.,Gardberg, A.,Glaser, N.,Goutopoulos, A.,Head, J.,Johnson, T.,Maurer, C.,Georgi, K.,Grenningloh, R.,Fang, Z.,Morandi, F.,Rohdich, F.,Schmidt, R.,Follis, A.V.,Sherer, B. Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity. Chemmedchem, 16:3653-3662, 2021 Cited by PubMed: 34582626DOI: 10.1002/cmdc.202100453 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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