7R60

BTK in complex with 18A

Summary for 7R60

• Entry DOI: 10.2210/pdb7r60/pdb
• Descriptor: Tyrosine-protein kinase BTK, 2-(4-phenoxyphenoxy)-5-[(3R)-1-(prop-2-enoyl)piperidin-3-yl]pyridine-3-carboxamide (3 entities in total)
• Functional Keywords: kinase, kinase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 32043.80

Authors

Gardberg, A. (deposition date: 2021-06-22, release date: 2021-10-06, Last modification date: 2023-10-18)

• Primary citation: Qiu, H.,Ali, Z.,Bowlan, J.,Caldwell, R.,Gardberg, A.,Glaser, N.,Goutopoulos, A.,Head, J.,Johnson, T.,Maurer, C.,Georgi, K.,Grenningloh, R.,Fang, Z.,Morandi, F.,Rohdich, F.,Schmidt, R.,Follis, A.V.,Sherer, B.; Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity.; Chemmedchem, 16:3653-3662, 2021; PubMed: 34582626; DOI: 10.1002/cmdc.202100453

Experimental method

X-RAY DIFFRACTION (1.94 Å)