PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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2Z2S	Crystal Structure of Rhodobacter sphaeroides SigE in complex with the anti-sigma ChrR 分子名称: Anti-Sigma factor ChrR, transcriptional activator ChrR, RpoE, ... 著者 Darst, S.A, Campbell, E.A. 登録日 2007-05-26 公開日 2008-02-05 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Mol.Cell, 27, 2007
7KTP	PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome 分子名称: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... 著者 Grau, D.J, Armache, K.J. 登録日 2020-11-24 公開日 2021-02-03 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
7YHJ	Effector binding domain of LysR-Type transcription factor LrhA from E. coli 分子名称: DI(HYDROXYETHYL)ETHER, Probable HTH-type transcriptional regulator LrhA, SULFATE ION 著者 Xie, C, Jiang, X. 登録日 2022-07-13 公開日 2022-08-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.237 Å) 主引用文献 Effector binding domain of LysR-Type transcription factor LrhA from E. coli To Be Published
3DEU	Crystal structure of transcription regulatory protein slyA from Salmonella typhimurium in complex with salicylate ligands 分子名称: 2-HYDROXYBENZOIC ACID, Transcriptional regulator slyA 著者 Le Trong, I, Brzovic, P.S, Fang, F.C, Libby, S.J, Stenkamp, R.E. 登録日 2008-06-10 公開日 2008-06-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Evolution of SlyA/RovA Transcription Factors from Repressors to Countersilencers in Enterobacteriaceae . Mbio, 10, 2019
5FA5	Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Histone H4, Methylosome protein 50, ... 著者 Sprague, E.R, McNamara, J.T. 登録日 2015-12-10 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science, 351, 2016
3BT9	crystal structure of QacR(E57Q) bound to Dequalinium 分子名称: DEQUALINIUM, HTH-type transcriptional regulator qacR, SULFATE ION 著者 Shumacher, M.A, Schuman, J.T, Brennan, R.G. 登録日 2007-12-28 公開日 2008-08-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization Biochemistry, 47, 2008
3BTI	crystal structure of QacR(E58Q) bound to berberine 分子名称: BERBERINE, HTH-type transcriptional regulator qacR, SULFATE ION 著者 Schumacher, M.A, Schuman, J.T, Brennan, R.G. 登録日 2007-12-28 公開日 2008-08-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization Biochemistry, 47, 2008
2FJ1	Crystal Structure Analysis of Tet Repressor (class D) in Complex with 7-Chlortetracycline-Nickel(II) 分子名称: 7-CHLOROTETRACYCLINE, CHLORIDE ION, NICKEL (II) ION, ... 著者 Orth, P, Saenger, W, Palm, G.J, Hinrichs, W. 登録日 2005-12-30 公開日 2007-01-09 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex. J.Biol.Inorg.Chem., 13, 2008
7NSQ	Structure of ErmDL-Telithromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Beckert, B, Wilson, D.N. 登録日 2021-03-08 公開日 2021-07-14 最終更新日 2021-08-11 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics. Nat Commun, 12, 2021
7NSO	Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with P-tRNA 分子名称: 16S rRNA (1540-MER), 23S rRNA (2903-MER), 30S ribosomal protein S10, ... 著者 Beckert, B, Wilson, D.N. 登録日 2021-03-08 公開日 2021-07-14 最終更新日 2021-08-11 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics. Nat Commun, 12, 2021
7NSP	Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Beckert, B, Wilson, D.N. 登録日 2021-03-08 公開日 2021-08-11 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics. Nat Commun, 12, 2021
7KSO	Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 分子名称: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... 著者 Grau, D.J, Armache, K.J. 登録日 2020-11-23 公開日 2021-02-03 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
7KSR	PRC2:EZH1_A from a dimeric PRC2 bound to a nucleosome 分子名称: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... 著者 Grau, D.J, Armache, K.J. 登録日 2020-11-24 公開日 2021-02-03 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
3BR3	Crystal Structure of the Complex of Ethidium Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor 分子名称: ETHIDIUM, HTH-type transcriptional regulator qacR, SULFATE ION 著者 Brooks, B.E. 登録日 2007-12-20 公開日 2008-12-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Formal electrostatic interactions do not govern QacR-cation affinity To be Published
4L5I	Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition 分子名称: Transcriptional regulator LsrR 著者 Ryu, K.S, Ha, J.H, Eo, Y. 登録日 2013-06-11 公開日 2013-11-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition. J.Am.Chem.Soc., 135, 2013
4L5J	Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition 分子名称: 5-O-phosphono-alpha-D-ribofuranose, Transcriptional regulator LsrR 著者 Ryu, K.S, Ha, J.H, Eo, Y. 登録日 2013-06-11 公開日 2013-11-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition. J.Am.Chem.Soc., 135, 2013
6YUH	Crystal structure of SMYD3 with diperodon R enantiomer bound to allosteric site 分子名称: Diperodon, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Cederfelt, D, Talibov, V.O, Dobritzsch, D, Danielson, U.H. 登録日 2020-04-27 公開日 2021-01-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase. Chembiochem, 22, 2021
3TPE	The phipa p3121 structure 分子名称: Serine/threonine-protein kinase HipA 著者 Schumacher, M.A, Link, T, Brennan, R.G. 登録日 2011-09-07 公開日 2012-10-03 最終更新日 2018-03-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
6ZHC	PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL 分子名称: 1,2-ETHANEDIOL, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]-5-[3-[4-[3-[2-[2-[2-[2-[2-[3-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]phenoxy]propyl]-1,3-thiazole-4-carboxylic acid, Bcl-2-like protein 1, ... 著者 Chung, C. 登録日 2020-06-22 公開日 2020-08-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. Acs Chem.Biol., 15, 2020
6YZ3	PqsR (MvfR) in complex with antagonist 19 分子名称: 1,2-ETHANEDIOL, 6-chloranyl-3-[(2-hexyl-2,3-dihydro-1,3-thiazol-4-yl)methyl]quinazolin-4-one, LysR family transcriptional regulator 著者 Richardson, W.K, Emsley, J. 登録日 2020-05-06 公開日 2020-09-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. Eur.J.Med.Chem., 208, 2020
6U48	E. coli 50S with phazolicin (PHZ) bound in exit tunnel 分子名称: 23S rRNA, 50S ribosomal protein bL17, 50S ribosomal protein bL19, ... 著者 Watson, Z.L, Cate, J.H.D, Polikanov, Y.S, Severinov, K. 登録日 2019-08-23 公開日 2019-09-18 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition. Nat Commun, 10, 2019
6Z07	PqsR (MvfR) in complex with antagonist 12 分子名称: 3-[(2-~{tert}-butyl-1,3-thiazol-4-yl)methyl]-6-chloranyl-quinazolin-4-one, GLYCEROL, Transcriptional regulator MvfR 著者 Richardson, W.K, Emsley, J. 登録日 2020-05-07 公開日 2020-09-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. Eur.J.Med.Chem., 208, 2020
6Z5K	PqsR (MvfR) in complex with antagonist 18 分子名称: 6-chloranyl-3-[(2-pentyl-2,3-dihydro-1,3-thiazol-4-yl)methyl]quinazolin-4-one, Transcriptional regulator MvfR 著者 Richardson, W.K, Emsley, J. 登録日 2020-05-26 公開日 2020-09-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.201 Å) 主引用文献 Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. Eur.J.Med.Chem., 208, 2020
3TPB	Structure of HipA(S150A) 分子名称: CHLORIDE ION, PHOSPHATE ION, Serine/threonine-protein kinase HipA 著者 schumacher, M.A. 登録日 2011-09-07 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
6Z7O	Crystal structure of Thioredoxin T from Drosophila melanogaster 分子名称: Thioredoxin-T, ZINC ION 著者 Freier, R, Aragon, E, Baginski, B, Pluta, R, Martin-Malpartida, P, Torner, C, Gonzaez, C, Macias, M. 登録日 2020-05-31 公開日 2020-10-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins. Iucrj, 8, 2021

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