PDB: 221 件ウェブページステータス検索Chemie searchBIRD

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5YQN	Crystal structure of Sirt2 in complex with selective inhibitor L55 分子名称: DI(HYDROXYETHYL)ETHER, N-[3-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ... 著者 Wang, H, Yu, Y, Li, G, Chen, Q. 登録日 2017-11-07 公開日 2018-10-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
5Y4H	Human SIRT3 in complex with halistanol sulfate 分子名称: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, THr-Arg-Ser-GLY-ALY-VAL-MET-ARG-ARG-LEU-ARG-ARG, ... 著者 Kudo, N, Ito, A, Yoshida, M. 登録日 2017-08-03 公開日 2018-05-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria J. Antibiot., 71, 2018
5Y2F	Human SIRT6 in complex with allosteric activator MDL-801 分子名称: 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid, 9-mer peptide QTARKSTGG, DI(HYDROXYETHYL)ETHER, ... 著者 Zhang, J, Huang, Z, Song, K. 登録日 2017-07-25 公開日 2018-11-07 最終更新日 2018-11-28 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Identification of a cellularly active SIRT6 allosteric activator. Nat. Chem. Biol., 14, 2018
5YTK	Crystal structure of SIRT3 bound to a leucylated AceCS2 分子名称: AceCS2-KLeu, LEUCINE, LYSINE, ... 著者 Li, J, Gong, W, Xu, Y. 登録日 2017-11-18 公開日 2017-12-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations Cell Metab., 27, 2018
5YQO	Crystal structure of Sirt2 in complex with selective inhibitor L5C 分子名称: N-[4-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION 著者 Wang, H, Yu, Y, Li, G, Chen, Q. 登録日 2017-11-07 公開日 2018-10-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.483 Å) 主引用文献 X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
5YQL	Crystal structure of Sirt2 in complex with selective inhibitor A2I 分子名称: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[3-(phenoxymethyl)phenyl]ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ... 著者 Wang, H, Yu, Y, Li, G, Chen, Q. 登録日 2017-11-07 公開日 2018-10-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.601 Å) 主引用文献 X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
5YQM	Crystal structure of Sirt2 in complex with selective inhibitor A29 分子名称: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-(4-phenylsulfanylphenyl)ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ... 著者 Wang, H, Yu, Y, Li, G, chen, Q. 登録日 2017-11-07 公開日 2018-10-17 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.735 Å) 主引用文献 X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
5Z94	Crystal Structure of SIRT3 in complex with H3K4bhb peptide 分子名称: CITRIC ACID, GLYCEROL, Gene for histone H3 (germline gene), ... 著者 Zhang, X, Li, H. 登録日 2018-02-02 公開日 2019-02-06 実験手法 X-RAY DIFFRACTION (1.899 Å) 主引用文献 Crystal Structure of SIRT3 in complex with H3K4bhb peptide To Be Published
5ZGC	Crystal Structure of SIRT3 in complex with H4K16bhb peptide 分子名称: Histone H4K16bhb peptide, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ... 著者 Li, H, Zhang, X. 登録日 2018-03-08 公開日 2019-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal Structure of SIRT3 in complex with H4K16bhb peptide To be published
5Z93	Crystal Structure of SIRT3 in complex with H3K9bhb peptide 分子名称: Gene for histone H3 (germline gene), NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ... 著者 Zhang, X, Li, H. 登録日 2018-02-02 公開日 2019-02-06 実験手法 X-RAY DIFFRACTION (1.945 Å) 主引用文献 Crystal Structure of SIRT3 in complex with H3K9bhb peptide To Be Published
6ACL	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H2AK95 分子名称: NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION, ... 著者 Hang, T.R, Chen, W.B. 登録日 2018-07-26 公開日 2019-07-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H2AK95 To Be Published
6ACP	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H4K91 分子名称: NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION, ... 著者 Hang, T.R, Chen, W.B. 登録日 2018-07-26 公開日 2019-07-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H4K91 To Be Published
6ACE	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H3K122 分子名称: GLYCEROL, NAD-dependent protein deacylase sirtuin-5, mitochondrial, ... 著者 Hang, T.R, Chen, W.B. 登録日 2018-07-26 公開日 2019-07-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H3K122 To Be Published
6ACO	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H2BK120 分子名称: CHLORIDE ION, GLYCEROL, NAD-dependent protein deacylase sirtuin-5, ... 著者 Hang, T.R, Chen, W.B. 登録日 2018-07-26 公開日 2019-07-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H2BK120 To Be Published
4IAO	Crystal structure of Sir2 C543S mutant in complex with SID domain of Sir4 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, NAD-dependent histone deacetylase SIR2, Regulatory protein SIR4, ... 著者 Hsu, H.C, Wang, C.L, Wang, M, Yang, N, Chen, Z, Sternglanz, R, Xu, R.M. 登録日 2012-12-07 公開日 2012-12-26 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding Genes Dev., 27, 2013
2HJH	Crystal Structure of the Sir2 deacetylase 分子名称: (2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE, NAD-dependent histone deacetylase SIR2, NICOTINAMIDE, ... 著者 Hall, B.E, Ellenberger, T.E. 登録日 2006-06-30 公開日 2008-04-08 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Autoregulation of the yeast Sir2 deacetylase by reaction and trapping of a pseudosubstrate motif in the active site To be Published
8BBK	Crystal structure of human Sirt3 in complex with a fragment of the human AROS protein 分子名称: Active regulator of SIRT1, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ... 著者 Steegborn, C, Weiss, S. 登録日 2022-10-13 公開日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein. Int J Mol Sci, 23, 2022
8CCZ	Crystal structure of human Sirt3 in complex with an inhibiting HIV1 Tat-37-59 peptide 分子名称: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Protein Tat, ... 著者 Adolph, R.S, Steegborn, C. 登録日 2023-01-28 公開日 2023-05-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein. Life, 13, 2023
8F86	SIRT6 bound to an H3K9Ac nucleosome 分子名称: DNA (148-MER), Histone H2A type 1, Histone H2B, ... 著者 Markert, J, Whedon, S, Wang, Z, Cole, P, Farnung, L. 登録日 2022-11-21 公開日 2023-04-05 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation. J.Am.Chem.Soc., 145, 2023
8OF4	Nucleosome Bound human SIRT6 (Composite) 分子名称: DNA (145-MER), Histone H2A type 1, Histone H2B, ... 著者 Smirnova, E, Bignon, E, Schultz, P, Papai, G, Ben-Shem, A. 登録日 2023-03-13 公開日 2023-08-09 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Binding to nucleosome poises human SIRT6 for histone H3 deacetylation. Elife, 12, 2024
8G57	Structure of nucleosome-bound Sirtuin 6 deacetylase 分子名称: DNA strand 1, DNA strand 2, Histone H2A type 1-B/E, ... 著者 Chio, U.S, Rechiche, O, Bryll, A.R, Zhu, J, Feldman, J.L, Peterson, C.L, Tan, S, Armache, J.-P. 登録日 2023-02-11 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Cryo-EM structure of the human Sirtuin 6-nucleosome complex. Sci Adv, 9, 2023

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