4IAO
Crystal structure of Sir2 C543S mutant in complex with SID domain of Sir4
Summary for 4IAO
Entry DOI | 10.2210/pdb4iao/pdb |
Descriptor | NAD-dependent histone deacetylase SIR2, Regulatory protein SIR4, ZINC ION, ... (5 entities in total) |
Functional Keywords | protein complex, sir2, deacetylase, nucleus, hydrolase-transcription complex, hydrolase/transcription |
Biological source | Saccharomyces cerevisiae More |
Cellular location | Nucleus, nucleolus: P06700 Nucleus: P11978 |
Total number of polymer chains | 4 |
Total formula weight | 148706.89 |
Authors | Hsu, H.C.,Wang, C.L.,Wang, M.,Yang, N.,Chen, Z.,Sternglanz, R.,Xu, R.M. (deposition date: 2012-12-07, release date: 2012-12-26, Last modification date: 2024-03-20) |
Primary citation | Hsu, H.C.,Wang, C.L.,Wang, M.,Yang, N.,Chen, Z.,Sternglanz, R.,Xu, R.M. Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding Genes Dev., 27:64-73, 2013 Cited by PubMed: 23307867DOI: 10.1101/gad.208140.112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.901 Å) |
Structure validation
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