2HJH

Crystal Structure of the Sir2 deacetylase

Summary for 2HJH

• Entry DOI: 10.2210/pdb2hjh/pdb
• Descriptor: NAD-dependent histone deacetylase SIR2, ZINC ION, (2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE, ... (5 entities in total)
• Functional Keywords: protein, sirtuin, acetyl-adp-ribose, nicotinamide, hydrolase
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Nucleus, nucleolus : P06700
• Total number of polymer chains: 2
• Total formula weight: 82977.76

Authors

Hall, B.E.,Ellenberger, T.E. (deposition date: 2006-06-30, release date: 2008-04-08, Last modification date: 2017-10-18)

• Primary citation: Hall, B.E.,Buchberger, J.R.,Gerber, S.A.,Ambrosio, A.L.B.,Gygi, S.P.,Filman, D.,Moazed, D.,Ellenberger, T.; Autoregulation of the yeast Sir2 deacetylase by reaction and trapping of a pseudosubstrate motif in the active site; To be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)