2HJH

Crystal Structure of the Sir2 deacetylase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NAD-dependent histone deacetylase SIR2	polymer	354	40700.0	2	UniProt (P06700) Pfam (PF04574) Pfam (PF02146)	Saccharomyces cerevisiae (baker's yeast)	Regulatory protein SIR2, Silent information regulator 2
2	C, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, G (A, B)	(2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE	non-polymer		601.4	2	Chemie (XYQ)
4	E, H (A, B)	NICOTINAMIDE	non-polymer		122.1	2	Chemie (NCA)
5	I, J (A, B)	water	water		18.0	517	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	81400.0
Non-Polymers*	Number of molecules	6
	Total formula weight	1577.8
All*	Total formula weight	82977.8

*Water molecules are not included.