8G57

Structure of nucleosome-bound Sirtuin 6 deacetylase

Summary for 8G57

• Entry DOI: 10.2210/pdb8g57/pdb
• EMDB information: 29735
• Descriptor: NAD-dependent protein deacylase sirtuin-6, Histone H3, Histone H4, ... (7 entities in total)
• Functional Keywords: nucleosome, sirt6, aging, dna damage, repair, deacetylation, diacylation, apo, chromatin, heterochromatin, gene regulation, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 11
• Total formula weight: 237406.24

Authors

Chio, U.S.,Rechiche, O.,Bryll, A.R.,Zhu, J.,Feldman, J.L.,Peterson, C.L.,Tan, S.,Armache, J.-P. (deposition date: 2023-02-11, release date: 2023-04-26)

• Primary citation: Chio, U.S.,Rechiche, O.,Bryll, A.R.,Zhu, J.,Leith, E.M.,Feldman, J.L.,Peterson, C.L.,Tan, S.,Armache, J.P.; Cryo-EM structure of the human Sirtuin 6-nucleosome complex.; Sci Adv, 9:eadf7586-eadf7586, 2023; PubMed: 37058572; DOI: 10.1126/sciadv.adf7586

Experimental method

ELECTRON MICROSCOPY (3.07 Å)