8G57
Structure of nucleosome-bound Sirtuin 6 deacetylase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (K) | NAD-dependent protein deacylase sirtuin-6 | polymer | 360 | 39708.5 | 1 | UniProt (Q8N6T7) Pfam (PF02146) | Homo sapiens (human) | NAD-dependent protein deacetylase sirtuin-6,Protein mono-ADP-ribosyltransferase sirtuin-6,Regulatory protein SIR2 homolog 6,hSIRT6,SIR2-like protein 6 |
| 2 | B, F (A, E) | Histone H3 | polymer | 132 | 15004.6 | 2 | UniProt (A0A310TTQ1) Pfam (PF00125) UniProt (by SIFTS) (P84233) | Xenopus laevis (African clawed frog) | |
| 3 | C, G (B, F) | Histone H4 | polymer | 85 | 9704.4 | 2 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 4 | D, H (C, G) | Histone H2A type 1-B/E | polymer | 129 | 14034.4 | 2 | UniProt (P04908) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (human) | Histone H2A.2,Histone H2A/a,Histone H2A/m |
| 5 | E, I (D, H) | Histone H2B type 1-J | polymer | 125 | 13804.0 | 2 | UniProt (P06899) Pfam (PF00125) | Homo sapiens (human) | Histone H2B.1,Histone H2B.r,H2B/r |
| 6 | J (I) | DNA strand 1 | polymer | 150 | 46541.6 | 1 | synthetic construct | ||
| 7 | K (J) | DNA strand 2 | polymer | 150 | 46061.3 | 1 | synthetic construct |
Sequence modifications
K: 1 - 355 (UniProt: Q8N6T7)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 46 | Ser 46 | variant |
| Lys 356 | - | expression tag |
| Leu 357 | - | expression tag |
| Asn 358 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 237406.2 | |
| All* | Total formula weight | 237406.2 |
