PDB: 340 件ウェブページステータス検索Chemie searchBIRD

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3M59	SET7/9 Y245A in complex with TAF10-K189me2 peptide and AdoHcy 分子名称: COBALT (II) ION, GLYCEROL, Histone-lysine N-methyltransferase SETD7, ... 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
3M54	SET7/9 Y305F in complex with TAF10 peptide and AdoHcy 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10 peptide 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
3M57	SET7/9 Y245A in complex with TAF10 peptide and AdoHcy 分子名称: GLYCEROL, Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
3MO2	human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 分子名称: 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... 著者 Chang, Y, Horton, J.R, Cheng, X. 登録日 2010-04-22 公開日 2010-06-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
6MBP	GLP Methyltransferase with Inhibitor EML741- P3121 Crystal Form 分子名称: 1,2-ETHANEDIOL, 2-cyclohexyl-7-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-8-[3-(pyrrolidin-1-yl)propoxy]-3H-1,4-benzodiazepin-5-amine, Histone-lysine N-methyltransferase EHMT1, ... 著者 Horton, J.R, Cheng, X. 登録日 2018-08-30 公開日 2019-02-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.947 Å) 主引用文献 Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure. J. Med. Chem., 62, 2019
6MBJ	SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, P21 Crystal Form 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Actin Peptide, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2018-08-30 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature, 565, 2019
6JAT	Crystal structure of SETD3 bound to Actin peptide and SFG 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Actin, gamma-enteric smooth muscle, ... 著者 Li, H, Zheng, Y. 登録日 2019-01-25 公開日 2020-01-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.713 Å) 主引用文献 Crystal structure of SETD3 bound to Actin peptide and SFG to be published
3M58	SET7/9 Y245A in complex with TAF10-K189me1 peptide and AdoHcy 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
3M5A	SET7/9 Y245A in complex with TAF10-K189me3 peptide and AdoHcy 分子名称: COBALT (II) ION, GLYCEROL, Histone-lysine N-methyltransferase SETD7, ... 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
3MO5	Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 分子名称: 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... 著者 Chang, Y, Horton, J.R, Cheng, X. 登録日 2010-04-22 公開日 2010-06-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
6MBK	SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, First P212121 Crystal Form 分子名称: 1,2-ETHANEDIOL, Actin peptide, GLYCEROL, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2018-08-30 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature, 565, 2019
3M56	SET7/9 Y305F in complex with TAF10-K189me2 peptide and AdoHcy 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10-K189me2 PEPTIDE 著者 Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. 登録日 2010-03-12 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
3N71	Crystal structure of cardiac specific histone methyltransferase SmyD1 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Histone lysine methyltransferase SmyD1, ... 著者 Sirinupong, N, Yang, Z. 登録日 2010-05-26 公開日 2010-10-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site Architecture. J.Biol.Chem., 285, 2010
6MBO	GLP Methyltransferase with Inhibitor EML741-P212121 Crystal Form 分子名称: 1,2-ETHANEDIOL, 2-cyclohexyl-7-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-8-[3-(pyrrolidin-1-yl)propoxy]-3H-1,4-benzodiazepin-5-amine, Histone-lysine N-methyltransferase EHMT1, ... 著者 Horton, J.R, Cheng, X. 登録日 2018-08-30 公開日 2019-02-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.591 Å) 主引用文献 Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure. J. Med. Chem., 62, 2019
6MBL	SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, Second P212121 Crystal Form 分子名称: 1,2-ETHANEDIOL, Actin Peptide, Histone-lysine N-methyltransferase setd3, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2018-08-30 公開日 2018-12-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.197 Å) 主引用文献 SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature, 565, 2019
6J9J	crystal structure of SESTD2 in complex with H3.3S31phK36M peptide 分子名称: H3.3S31phK36M(29-42), Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Yang, S, Li, H.T. 登録日 2019-01-23 公開日 2020-02-26 最終更新日 2020-08-12 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Histone H3.3 phosphorylation amplifies stimulation-induced transcription. Nature, 583, 2020
6N3G	Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol 分子名称: DODECAETHYLENE GLYCOL, ETHANOL, N-lysine methyltransferase SMYD2, ... 著者 Perry, E, Spellmon, N, Brunzelle, J, Yang, Z. 登録日 2018-11-15 公開日 2019-11-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol To be Published
3OPE	Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase 分子名称: Probable histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ZINC ION 著者 An, S, Song, J. 登録日 2010-08-31 公開日 2011-01-12 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism J.Biol.Chem., 286, 2011
3OS5	SET7/9-Dnmt1 K142me1 complex 分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Dnmt1, ... 著者 Esteve, P.-O, Chang, Y, Samaranayake, M, Upadhyay, A.K, Horton, J.R, Feehery, G.R, Cheng, X, Pradhan, S. 登録日 2010-09-08 公開日 2010-12-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat.Struct.Mol.Biol., 18, 2011
3OXG	human lysine methyltransferase Smyd3 in complex with AdoHcy (Form III) 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION 著者 Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. 登録日 2010-09-21 公開日 2011-02-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res., 39, 2011
3OOI	Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine 分子名称: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, S-ADENOSYLMETHIONINE, ... 著者 Qiao, Q, Wang, M, Xu, R.M. 登録日 2010-08-31 公開日 2010-12-22 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation J.Biol.Chem., 286, 2010
3OXF	Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form I) 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION 著者 Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. 登録日 2010-09-21 公開日 2011-02-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding. Nucleic Acids Res., 39, 2011
3OXL	Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form II) 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION 著者 Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. 登録日 2010-09-21 公開日 2011-02-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding Nucleic Acids Res., 39, 2011
3QWW	Crystal structure of histone lysine methyltransferase SmyD2 in complex with the methyltransferase inhibitor sinefungin 分子名称: SET and MYND domain-containing protein 2, SINEFUNGIN, ZINC ION 著者 Jiang, Y, Sirinupong, N, Brunzelle, J, Yang, Z. 登録日 2011-02-28 公開日 2011-07-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain. Plos One, 6, 2011
3QXY	Human SETD6 in complex with RelA Lys310 分子名称: 1,2-ETHANEDIOL, N-lysine methyltransferase SETD6, S-ADENOSYLMETHIONINE, ... 著者 Chang, Y, Levy, D, Horton, J.R, Peng, J, Zhang, X, Gozani, O, Cheng, X. 登録日 2011-03-02 公開日 2011-05-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Res., 39, 2011

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