6MBK

SETD3, a Histidine Methyltransferase, in Complex with an Actin Peptide and SAH, First P212121 Crystal Form

Summary for 6MBK

• Entry DOI: 10.2210/pdb6mbk/pdb
• Descriptor: Actin peptide, Histone-lysine N-methyltransferase setd3, S-ADENOSYL-L-HOMOCYSTEINE, ... (7 entities in total)
• Functional Keywords: transferase, transferase-structural protein complex, transferase/structural protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 141473.43

Authors

Horton, J.R.,Dai, S.,Cheng, X. (deposition date: 2018-08-30, release date: 2018-12-19, Last modification date: 2023-10-11)

• Primary citation: Wilkinson, A.W.,Diep, J.,Dai, S.,Liu, S.,Ooi, Y.S.,Song, D.,Li, T.M.,Horton, J.R.,Zhang, X.,Liu, C.,Trivedi, D.V.,Ruppel, K.M.,Vilches-Moure, J.G.,Casey, K.M.,Mak, J.,Cowan, T.,Elias, J.E.,Nagamine, C.M.,Spudich, J.A.,Cheng, X.,Carette, J.E.,Gozani, O.; SETD3 is an actin histidine methyltransferase that prevents primary dystocia.; Nature, 565:372-376, 2019; PubMed: 30626964; DOI: 10.1038/s41586-018-0821-8

Experimental method

X-RAY DIFFRACTION (1.69 Å)