PDB: 2239 件ウェブページステータス検索Chemie searchBIRD

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4A9H	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one 分子名称: (2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE, 1,2-ETHANEDIOL, BROMODOMAIN-CONTAINING PROTEIN 2, ... 著者 Chung, C.W, Bamborough, P. 登録日 2011-11-26 公開日 2012-01-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55, 2012
8OU2	Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor 分子名称: 1,2-ETHANEDIOL, 7-(1-cyclopropylpyrazol-4-yl)-2-[[2-fluoranyl-4-(4-methylpiperazin-1-yl)sulfonyl-phenyl]amino]-3-methyl-pyrido[1,2-a]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... 著者 Balikci, E, Ni, X, Bountra, C, von Delft, F, Huber, K. 登録日 2023-04-21 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor To Be Published
4A9N	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-cyclopropyl-5-(3,5- dimethyl-1,2-oxazol-4-yl)-2-methylbenzene-1-sulfonamide 分子名称: 1,2-ETHANEDIOL, BROMODOMAIN CONTAINING 2, DIMETHYL SULFOXIDE, ... 著者 Chung, C, Bamborough, P. 登録日 2011-11-26 公開日 2012-02-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides. J.Med.Chem., 55, 2012
4AKN	N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid 分子名称: 1,2-ETHANEDIOL, 4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid, BROMODOMAIN-CONTAINING PROTEIN 2, ... 著者 Chung, C, Lamotte, Y, Donche, F, Bouillot, A, Mirguet, O. 登録日 2012-02-26 公開日 2012-07-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A). Bioorg.Med.Chem.Lett., 22, 2012
4A9L	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1,3-DIMETHYL-6-(MORPHOLINE- 4-SULFONYL)-1,2,3,4-TETRAHYDROQUINAZOLIN-2-ONE 分子名称: 1,2-ETHANEDIOL, 1,3-dimethyl-6-(morpholin-4-ylsulfonyl)-3,4-dihydroquinazolin-2(1H)-one, BROMODOMAIN-CONTAINING PROTEIN 4, ... 著者 Chung, C.W, Bamborough, P. 登録日 2011-11-26 公開日 2012-01-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55, 2012
4A9O	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 5 ethyl-3-methyl-4-phenyl-1, 2-oxazole 分子名称: 1,2-ETHANEDIOL, 5-ETHYL-3-METHYL-4-PHENYL-1,2-OXAZOLE, BROMODOMAIN CONTAINING 2, ... 著者 Chung, C.W, Bamborough, P. 登録日 2011-11-26 公開日 2012-02-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides. J.Med.Chem., 55, 2012
4A9F	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-METHYLPYRROLIDIN-2-ONE 分子名称: 1,2-ETHANEDIOL, 1-methylpyrrolidin-2-one, BROMODOMAIN-CONTAINING PROTEIN 2, ... 著者 Chung, C.W, Bamborough, P. 登録日 2011-11-26 公開日 2012-01-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55, 2012
4ALH	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3,5 dimethyl-4-phenyl-1,2- oxazole 分子名称: 1,2-ETHANEDIOL, 3,5 DIMETHYL-4-PHENYL-1,2-OXAZOLE, BROMODOMAIN CONTAINING 2, ... 著者 Chung, C.W, Bamborough, P. 登録日 2012-03-03 公開日 2012-04-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides. J.Med.Chem., 55, 2012
4A9J	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-(4-hydroxyphenyl) acetamide 分子名称: 1,2-ETHANEDIOL, BROMODOMAIN CONTAINING 2, N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL), ... 著者 Chung, C.W, Bamborough, P. 登録日 2011-11-26 公開日 2012-01-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55, 2012
8PIQ	Crystal Structure of BRD4-BD1 with BI894999 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ... 著者 Kessler, D. 登録日 2023-06-22 公開日 2023-07-26 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.117 Å) 主引用文献 Crystal Structure of BRD4-BD1 with BI894999 To Be Published
8F6G	Crystal structure of BPTF bromodomain in complex with BZ2 分子名称: 6-[4-(2-aminoethyl)anilino]-5-chloro-3-methylpyrimidin-4(3H)-one, Nucleosome-remodeling factor subunit BPTF 著者 Nithianantham, S, Fischer, M. 登録日 2022-11-16 公開日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of BPTF bromodomain in complex with BZ2 To Be Published
4A9E	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3-methyl-1,2,3,4- tetrahydroquinazolin-2-one 分子名称: 1,2-ETHANEDIOL, 3-methyl-3,4-dihydroquinazolin-2(1H)-one, BROMODOMAIN-CONTAINING PROTEIN 2, ... 著者 Chung, C, Bamborough, P. 登録日 2011-11-26 公開日 2012-01-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55, 2012
8PX2	C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1,3-dimethyl-5-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one 分子名称: 1,3-dimethyl-5-[1-(oxan-4-ylmethyl)benzimidazol-2-yl]pyridin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Bromodomain-containing protein 2 著者 Chung, C.W. 登録日 2023-07-22 公開日 2023-10-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.622 Å) 主引用文献 Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. J.Med.Chem., 66, 2023
8PXM	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH (1R,1'R)-7,7'-(pentane-1,5-diylbis(oxy))bis(1,3-dimethyl-1,3-dihydro-2H-benzo[d]azepin-2-one) 分子名称: (1R)-7-[5-[[(1R)-1,3-dimethyl-2-oxidanylidene-1H-3-benzazepin-7-yl]oxy]pentoxy]-1,3-dimethyl-1H-3-benzazepin-2-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 著者 Chung, C.W. 登録日 2023-07-23 公開日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.378 Å) 主引用文献 Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors. Acs Med.Chem.Lett., 14, 2023
8PXA	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH (S)-5-(1-((1-(1-isopropylpiperidine-4-carbonyl)piperidin-3-yl)methyl)-1H-benzo[d]imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one 分子名称: 1,3-dimethyl-5-[1-[[(3~{S})-1-(1-propan-2-ylpiperidin-4-yl)carbonylpiperidin-3-yl]methyl]benzimidazol-2-yl]pyridin-2-one, Bromodomain-containing protein 4 著者 Chung, C. 登録日 2023-07-22 公開日 2023-10-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. J.Med.Chem., 66, 2023
8PX8	C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH (S)-5-(1-((1-acetylpiperidin-3-yl)methyl)-5-bromo-1H-benzo[d]imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[5-bromanyl-1-[[(3~{S})-1-ethanoylpiperidin-3-yl]methyl]benzimidazol-2-yl]-1,3-dimethyl-pyridin-2-one, ... 著者 Chung, C.W. 登録日 2023-07-22 公開日 2023-10-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.603 Å) 主引用文献 Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. J.Med.Chem., 66, 2023
8PXN	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH (1R,1'R)-7,7'-(ethane-1,2-diylbis(oxy))bis(1,3-dimethyl-1,3-dihydro-2H-benzo[d]azepin-2-one) 分子名称: (1R)-7-[2-[[(1R)-1,3-dimethyl-2-oxidanylidene-1H-3-benzazepin-7-yl]oxy]ethoxy]-1,3-dimethyl-1H-3-benzazepin-2-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 著者 Chung, C. 登録日 2023-07-23 公開日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.952 Å) 主引用文献 Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors. Acs Med.Chem.Lett., 14, 2023
4BJX	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726) 分子名称: 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid, BROMODOMAIN-CONTAINING PROTEIN 4 著者 Chung, C. 登録日 2013-04-20 公開日 2013-10-02 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Bet Inhibition Silences Expression of Mycn and Bcl2 and Induces Cytotoxicity in Neuroblastoma Tumor Models. Plos One, 8, 2013
4CFK	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH LY294002 分子名称: 1,2-ETHANEDIOL, 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE, BRD4 PROTEIN, ... 著者 Chung, C, Dittmann, A, Drewes, G. 登録日 2013-11-18 公開日 2014-01-15 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 The Commonly Used Pi3-Kinase Probe Ly294002 is an Inhibitor of Bet Bromodomains. Acs Chem.Biol., 9, 2014
2D82	Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association 分子名称: 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE, CREB-binding protein 著者 Sachchidanand, Resnick-Silverman, L, Yan, S, Mujtaba, S, Liu, W.J, Zeng, L, Manfredi, J.J, Zhou, M.M. 登録日 2005-12-01 公開日 2006-04-04 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Target structure-based discovery of small molecules that block human p53 and CREB binding protein association Chem.Biol., 13, 2006
2D9E	Solution structure of the Bromodomain of Peregrin 分子名称: Peregrin 著者 Hatta, R, Hayashi, F, Izumi, K, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-09 公開日 2006-06-09 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the Bromodomain of Peregrin To be published
2DAT	Solution structure of the Bromodomain of human SWI/SNF related matrix associated actin dependent regulator of cromatin subfamily A member 2 分子名称: Possible global transcription activator SNF2L2 著者 Yoneyama, M, Kigawa, T, Saito, K, Tochio, N, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-14 公開日 2007-01-02 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the Bromodomain of human SWI/SNF related matrix associated actin dependent regulator of cromatin subfamily A member 2 To be Published
2DWW	Crystal structure of Bromodomain-containing protein 4 分子名称: Bromodomain-containing protein 4, CHLORIDE ION 著者 Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-21 公開日 2007-08-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of Bromodomain-containing protein 4 To be Published
2DVV	Crystal structure of the second bromodomain of the human Brd2 protein 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bromodomain-containing protein 2 著者 Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-01 公開日 2007-08-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the second bromodomain of the human Brd2 protein To be Published
2E3K	Crystal structure of the human Brd2 second bromodomain in complexed with the acetylated histone H4 peptide 分子名称: 15-mer peptide from Histone H4, Bromodomain-containing protein 2 著者 Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-11-27 公開日 2007-12-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for diacetylated histone H4 tail recognition by the second bromodomain of human BRD2 To be Published

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