Crystal structure of ATAD2A bromodomain double mutant N1063A-Y1064A in apo form

Summary for 4TT6

Related4TT2 4TT4 4TTE 4TU4 4TU6
DescriptorATPase family AAA domain-containing protein 2, SULFATE ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsacetyllysine reader deficient bromodomain, gene regulation
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  Q6PL18
Total number of polymer chains1
Total molecular weight15542
Poncet-Montange, G.,Zhan, Y.,Bardenhagen, J.,Petrocchi, A.,Leo, E.,Shi, X.,Lee, G.,Leonard, P.,Geck Do, M.,Cardozo, M.,Palmer, W.,Andersen, J.,Jones, P.,Ladbury, J. (deposition date: 2014-06-19, release date: 2014-12-24, Last modification date: 2015-03-04)
Primary citation
Poncet-Montange, G.,Zhan, Y.,Bardenhagen, J.P.,Petrocchi, A.,Leo, E.,Shi, X.,Lee, G.R.,Leonard, P.G.,Geck Do, M.K.,Cardozo, M.G.,Andersen, J.N.,Palmer, W.S.,Jones, P.,Ladbury, J.E.
Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466:337-346, 2015
PubMed: 25486442 (PDB entries with the same primary citation)
DOI: 10.1042/BJ20140933
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19230 1.7% 7.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28